| |From Bench to Bedside and Back Again
Charles River has proudly partnered with the EBD Group to provide the scientific program for this year's BioPharm America™ Conference. Be a part of this two-day conference that aims to bridge the gap between drug discovery and clinical application.
|TABLE OF CONTENTS |
July 2017 Volume 35, Issue 7
Opinion and Comment
News and Views
Careers and Recruitment
| |NATURE CONFERENCE ON INFLAMMATORY DISEASES
Presented by: Chinese Academy of Medical Sciences & Peking Union Medical College | Chinese Society for Immunology (CSI) | Nature Reviews Immunology | Nature Immunology | Nature | Nature Communications
This conference will feature sessions on microbiota, cell death, metabolism, technologies, and innate sensing and signaling as they relate to inflammatory diseases and cancer.
September 17-20, 2017 | Beijing, China
Wanted: biotech for an aging population p597
Digital medicine's extraordinary ability to communicate with patients, especially in under-served communities, could help reorient the biotech industry to better address aging and its associated diseases.
CAR-Ts move beyond B-cell cancers to myeloma pp599 - 601
First state-approved embryonic stem cell trials in China p600
Merck KGaA, F-Star shake on immune-oncology bispecifics p601
Faster, deeper, smaller—the rise of antibody-like scaffolds pp602 - 603
AI-powered drug discovery captures pharma interest pp604 - 605
FDA deems in vitro data on mutations sufficient to expand cystic fibrosis drug label p606
Around the world in a month p607
| |Enhanced MALDI-TOF MS Performance and Flexibility
From a linear-only system to a unique QIT-TOF configuration to a high-resolution, high-energy TOF-TOF, Shimadzu's suite of MALDI mass spectrometers easily meets the needs of researchers with varying applications and budgets. Mine your data using our comprehensive software solutions.
|Building a business|
An emerging model for life sciences commercialization pp608 - 613
Ashley J Stevens
First rounders: Jan Vilcek p613
Opinion and Comment
Payer coverage policies for multigene tests pp614 - 617
Kathryn A Phillips, Patricia A Deverka, Julia R Trosman, Michael P Douglas, James D Chambers et al.
Consent and engagement, security, and authentic living using wearable and mobile health technology pp617 - 620
Karola V Kreitmair, Mildred K Cho and David C Magnus
FDA is the wrong agency to regulate genetically engineered animals pp620 - 622
John J Cohrssen and Henry I Miller
Public biotech in 2016—the numbers pp623 - 629
Chris Morrison and Riku Lahteenmaki
The anticipated decline in the biotech industry's ability to raise capital from public investors and an accompanying slump in biotech markets materialized in 2016, but all is not gloom and doom.
CRISPR-Cas9 claim sets and the potential to stifle innovation pp630 - 633
Benjamin N Gray and W Murray Spruill
Extremely broad claims surrounding Cas9 nucleases have the potential to stifle innovation in the field of genome editing.
Recent patents in optogenetics and optochemistry p634
News and Views
Single-cell genome sequencing at ultra-high-throughput with microfluidic droplet barcoding pp640 - 646
Freeman Lan, Benjamin Demaree, Noorsher Ahmed and Adam R Abate
More than 50,000 single-cell genomes are sequenced in a single run using droplet barcoding.
See also: News and Views by Tringe
Lipid production in Nannochloropsis gaditana is doubled by decreasing expression of a single transcriptional regulator pp647 - 652
Imad Ajjawi, John Verruto, Moena Aqui, Leah B Soriaga, Jennifer Coppersmith et al.
Lipid production in the oleaginous microalga Nannocholoropsis gaditana is doubled by decreasing the expression of a transcriptional regulator identified through a CRISPR-Cas9 reverse-genetics approach.
See also: News and Views by Posewitz
Engineered bacteria can function in the mammalian gut long-term as live diagnostics of inflammation pp653 - 658
David T Riglar, Tobias W Giessen, Michael Baym, S Jordan Kerns, Matthew J Niederhuber et al.
An engineered commensal E. coli strain can function as a living diagnostic for a marker of inflammation in the murine gut for 200 days.
Guided self-organization and cortical plate formation in human brain organoids pp659 - 666
Madeline A Lancaster, Nina S Corsini, Simone Wolfinger, E Hilary Gustafson, Alex W Phillips et al.
Engineering human brain organoids with floating scaffolds enhances the maturity and reproducibility of cortical tissue structure.
Computational design of trimeric influenza-neutralizing proteins targeting the hemagglutinin receptor binding site pp667 - 671
Eva-Maria Strauch, Steffen M Bernard, David La, Alan J Bohn, Peter S Lee et al.
A method to target trimeric membrane proteins by designing geometrically matched trimeric protein binders is demonstrated for the influenza-virus glycoprotein hemagglutinin.
Digital-to-biological converter for on-demand production of biologics pp672 - 675
Kent S Boles, Krishna Kannan, John Gill, Martina Felderman, Heather Gouvis et al.
Sequence information is converted into nucleic acids, proteins and phage particles without human intervention to enable on-demand bio-manufacturing.
1,003 reference genomes of bacterial and archaeal isolates expand coverage of the tree of life OPEN pp676 - 683
Supratim Mukherjee, Rekha Seshadri, Neha J Varghese, Emiley A Eloe-Fadrosh, Jan P Meier-Kolthoff et al.
Metagenomic and microbial sequence data are made easier to interpret with the addition of 1,003 genomes to the Genomic Encyclopedia of Bacteria and Archaea.
Careers and Recruitment
Unlocking Big Data for better health pp684 - 686
As the volume of biomedical data being created grows, so does the need for data analytics training for life science researchers.
| |Nature Awards for Mentoring in Science — Spain
Your mentor could win €10,000
Nominations are now open
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