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TABLE OF CONTENTS

July 2017 Volume 35, Issue 7

Editorial
News
Bioentrepreneur
Opinion and Comment
Features
News and Views
Research
Careers and Recruitment
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TLC/MS for Real-Time Reaction Monitoring of a Solution-Phase Peptide Synthesis

Real-time reaction monitoring based on a combination of thin-layer chromatography (TLC) and compact mass spectrometry (CMS) is a simple and quick way to identify reactants, products and side products of a chemical peptide synthesis reaction, providing detailed analyte detection.

Learn more.


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Nature Outlook: University Spin-offs 

This Outlook presents a portrait of 22 science-based start-up ventures that have emerged from universities around the world to turn laboratory research into practical, profitable products. 

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BIOPHARMA DEALMAKERS
BIOPHARMA DEALMAKERSCompany Profiles and Partnering Opportunities

 
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Nature Index China 2017

China continues to increase its global share of research papers, but publication numbers are just one indicator that a country's science is thriving.

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Presented by: Chinese Academy of Medical Sciences & Peking Union Medical College | Chinese Society for Immunology (CSI) | Nature Reviews Immunology | Nature Immunology | Nature | Nature Communications

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Editorial

Top

Wanted: biotech for an aging population   p597
doi:10.1038/nbt.3925
Digital medicine's extraordinary ability to communicate with patients, especially in under-served communities, could help reorient the biotech industry to better address aging and its associated diseases.

News

Top

CAR-Ts move beyond B-cell cancers to myeloma   pp599 - 601
Elie Dolgin
doi:10.1038/nbt0717-599

First state-approved embryonic stem cell trials in China   p600
doi:10.1038/nbt0717-600

Merck KGaA, F-Star shake on immune-oncology bispecifics   p601
doi:10.1038/nbt0717-601

Faster, deeper, smaller—the rise of antibody-like scaffolds   pp602 - 603
Brian Owens
doi:10.1038/nbt0717-602

AI-powered drug discovery captures pharma interest   pp604 - 605
Eric Smalley
doi:10.1038/nbt0717-604

FDA deems in vitro data on mutations sufficient to expand cystic fibrosis drug label   p606
Mark Ratner
doi:10.1038/nbt0717-606

Around the world in a month   p607
doi:10.1038/nbt0717-607


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Enhanced MALDI-TOF MS Performance and Flexibility 
From a linear-only system to a unique QIT-TOF configuration to a high-resolution, high-energy TOF-TOF, Shimadzu's suite of MALDI mass spectrometers easily meets the needs of researchers with varying applications and budgets. Mine your data using our comprehensive software solutions.
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Bioentrepreneur

Top
Building a business

An emerging model for life sciences commercialization   pp608 - 613
Ashley J Stevens
doi:10.1038/nbt.3911

Podcast

First rounders: Jan Vilcek   p613
doi:10.1038/nbt.3910

Opinion and Comment

Top
Correspondence

Payer coverage policies for multigene tests   pp614 - 617
Kathryn A Phillips, Patricia A Deverka, Julia R Trosman, Michael P Douglas, James D Chambers et al.
doi:10.1038/nbt.3912

Consent and engagement, security, and authentic living using wearable and mobile health technology   pp617 - 620
Karola V Kreitmair, Mildred K Cho and David C Magnus
doi:10.1038/nbt.3887

FDA is the wrong agency to regulate genetically engineered animals   pp620 - 622
John J Cohrssen and Henry I Miller
doi:10.1038/nbt.3915

Features

Top

Public biotech in 2016—the numbers   pp623 - 629
Chris Morrison and Riku Lahteenmaki
doi:10.1038/nbt.3917
The anticipated decline in the biotech industry's ability to raise capital from public investors and an accompanying slump in biotech markets materialized in 2016, but all is not gloom and doom.

Patents

CRISPR-Cas9 claim sets and the potential to stifle innovation   pp630 - 633
Benjamin N Gray and W Murray Spruill
doi:10.1038/nbt.3913
Extremely broad claims surrounding Cas9 nucleases have the potential to stifle innovation in the field of genome editing.

Recent patents in optogenetics and optochemistry   p634
doi:10.1038/nbt.3922


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Focus on Disease models: reproducibility and translation 

Lab Animal, a Nature Research journal focusing on in vivo methods, research and technology with model organisms of human health & disease, presents a special Focus on reproducibility and translation of in vivo research with disease models. 

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Produced with support from: 
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News and Views

Top

Single-cell genomics for the masses   pp635 - 636
Susannah G Tringe
doi:10.1038/nbt.3914
Microbial communities are rapidly sequenced at the single-cell level using droplet microfluidics.

See also: Research by Lan et al.

Algal oil productivity gets a fat bonus   pp636 - 638
Matthew C Posewitz
doi:10.1038/nbt.3920
Partitioning of carbon to lipids is engineered to improve oil accumulation in an industrial alga.

See also: Research by Ajjawi et al.

Research Highlights   p638
doi:10.1038/nbt.3921

Permeability rules for antibiotic design   p639
Susan Jones
doi:10.1038/nbt.3919

Research

Top
Articles

Single-cell genome sequencing at ultra-high-throughput with microfluidic droplet barcoding   pp640 - 646
Freeman Lan, Benjamin Demaree, Noorsher Ahmed and Adam R Abate
doi:10.1038/nbt.3880
More than 50,000 single-cell genomes are sequenced in a single run using droplet barcoding.

See also: News and Views by Tringe

Lipid production in Nannochloropsis gaditana is doubled by decreasing expression of a single transcriptional regulator   pp647 - 652
Imad Ajjawi, John Verruto, Moena Aqui, Leah B Soriaga, Jennifer Coppersmith et al.
doi:10.1038/nbt.3865
Lipid production in the oleaginous microalga Nannocholoropsis gaditana is doubled by decreasing the expression of a transcriptional regulator identified through a CRISPR-Cas9 reverse-genetics approach.

See also: News and Views by Posewitz

Letters

Engineered bacteria can function in the mammalian gut long-term as live diagnostics of inflammation   pp653 - 658
David T Riglar, Tobias W Giessen, Michael Baym, S Jordan Kerns, Matthew J Niederhuber et al.
doi:10.1038/nbt.3879
An engineered commensal E. coli strain can function as a living diagnostic for a marker of inflammation in the murine gut for 200 days.

Guided self-organization and cortical plate formation in human brain organoids   pp659 - 666
Madeline A Lancaster, Nina S Corsini, Simone Wolfinger, E Hilary Gustafson, Alex W Phillips et al.
doi:10.1038/nbt.3906
Engineering human brain organoids with floating scaffolds enhances the maturity and reproducibility of cortical tissue structure.

Computational design of trimeric influenza-neutralizing proteins targeting the hemagglutinin receptor binding site   pp667 - 671
Eva-Maria Strauch, Steffen M Bernard, David La, Alan J Bohn, Peter S Lee et al.
doi:10.1038/nbt.3907
A method to target trimeric membrane proteins by designing geometrically matched trimeric protein binders is demonstrated for the influenza-virus glycoprotein hemagglutinin.

Digital-to-biological converter for on-demand production of biologics   pp672 - 675
Kent S Boles, Krishna Kannan, John Gill, Martina Felderman, Heather Gouvis et al.
doi:10.1038/nbt.3859
Sequence information is converted into nucleic acids, proteins and phage particles without human intervention to enable on-demand bio-manufacturing.

Resources

1,003 reference genomes of bacterial and archaeal isolates expand coverage of the tree of life OPEN   pp676 - 683
Supratim Mukherjee, Rekha Seshadri, Neha J Varghese, Emiley A Eloe-Fadrosh, Jan P Meier-Kolthoff et al.
doi:10.1038/nbt.3886
Metagenomic and microbial sequence data are made easier to interpret with the addition of 1,003 genomes to the Genomic Encyclopedia of Bacteria and Archaea.

Careers and Recruitment

Top

Unlocking Big Data for better health   pp684 - 686
Steven Munevar
doi:10.1038/nbt.3918
As the volume of biomedical data being created grows, so does the need for data analytics training for life science researchers.

People

People   p688
doi:10.1038/nbt.3924

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