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Cell Death and Disease


Volume 8, July 2017

In this issue
News and Commentaries
Original Articles
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News and Commentaries


Yet another hump for CAML: support of cell survival independent of tail-anchored protein insertion

Jennifer C Shing and Richard J Bram

Cell Death Dis 2017 8: e2960; 10.1038/cddis.2017.334

Full Text

Cancer cell resistance to anoikis: MUC1 glycosylation comes to play

Lu-Gang Yu

Cell Death Dis 2017 8: e2962; 10.1038/cddis.2017.363

Abstract | Full Text



Acid sphingomyelinase mediates human CD4+ T-cell signaling: potential roles in T-cell responses and diseases

Aiping Bai and Yuan Guo

Cell Death Dis 2017 8: e2963; 10.1038/cddis.2017.360

Abstract | Full Text

Original Articles


Edaravone suppresses retinal ganglion cell death in a mouse model of normal tension glaucoma

Kei Akaiwa, Kazuhiko Namekata, Yuriko Azuchi, Xiaoli Guo, Atsuko Kimura, Chikako Harada, Yoshinori Mitamura and Takayuki Harada

Cell Death Dis 2017 8: e2934; 10.1038/cddis.2017.341

Abstract | Full Text

Epigallocatechin-3-gallate, a prototypic chemopreventative agent for protection against cisplatin-based ototoxicity

Vikrant Borse, Raheem F H Al Aameri, Kelly Sheehan, Sandeep Sheth, Tejbeer Kaur, Debashree Mukherjea, Srinivasan Tupal, Michelle Lowy, Sumana Ghosh, Asmita Dhukhwa, Puspanjali Bhatta, Leonard P Rybak and Vickram Ramkumar

Cell Death Dis 2017 8: e2921; 10.1038/cddis.2017.314

Abstract | Full Text

Mice lacking NF-κB1 exhibit marked DNA damage responses and more severe gastric pathology in response to intraperitoneal tamoxifen administration

Michael D Burkitt, Jonathan M Williams, Tristan Townsend, Rachael Hough and DMark Pritchard

Cell Death Dis 2017 8: e2939; 10.1038/cddis.2017.332

Abstract | Full Text

MicroRNA-148a deficiency promotes hepatic lipid metabolism and hepatocarcinogenesis in mice

Li Cheng, Yahui Zhu, Han Han, Qiang Zhang, Kaisa Cui, Hongxing Shen, Jinxiang Zhang, Jun Yan, Edward Prochownik and Youjun Li

Cell Death Dis 2017 8: e2916; 10.1038/cddis.2017.309

Abstract | Full Text

Impaired autophagosome clearance contributes to neuronal death in a piglet model of neonatal hypoxic-ischemic encephalopathy

Derong Cui, Dawei Sun, Xintao Wang, Liye Yi, Ewa Kulikowicz, Michael Reyes, Junchao Zhu, Zeng-Jin Yang, Wei Jiang and Raymond C Koehler

Cell Death Dis 2017 8: e2919; 10.1038/cddis.2017.318

Abstract | Full Text

The BH3-only proteins BIM and PUMA are not critical for the reticulocyte apoptosis caused by loss of the pro-survival protein BCL-XL

Alex RD Delbridge, Brandon J Aubrey, Craig Hyland, Jonathan P Bernardini, Ladina Di Rago, Jean-Marc Garnier, Guillaume Lessene, Andreas Strasser, Warren S Alexander and Stephanie Grabow

Cell Death Dis 2017 8: e2914; 10.1038/cddis.2017.304

Abstract | Full Text

Dickkopf1 destabilizes atherosclerotic plaques and promotes plaque formation by inducing apoptosis of endothelial cells through activation of ER stress

Mingxue Di, Lin Wang, Mengmeng Li, Yu Zhang, Xinxin Liu, Renya Zeng, Han Wang, Yifei Chen, Weijia Chen, Yun Zhang and Mei Zhang

Cell Death Dis 2017 8: e2917; 10.1038/cddis.2017.277

Abstract | Full Text

Inhibition of autophagy as a treatment strategy for p53 wild-type acute myeloid leukemia

Hendrik Folkerts, Susan Hilgendorf, Albertus T J Wierenga, Jennifer Jaques, André B Mulder, Paul J Coffer, Jan Jacob Schuringa and Edo Vellenga

Cell Death Dis 2017 8: e2927; 10.1038/cddis.2017.317

Abstract | Full Text

DNMT1-maintained hypermethylation of Krüppel-like factor 5 involves in the progression of clear cell renal cell carcinoma

Rong-Jie Fu, Wei He, Xiao-Bo Wang, Lei Li, Huan-Bin Zhao, Xiao-Ye Liu, Zhi Pang, Guo-Qiang Chen, Lei Huang and Ke-Wen Zhao

Cell Death Dis 2017 8: e2952; 10.1038/cddis.2017.323

Abstract | Full Text

Linc-DYNC2H1-4 promotes EMT and CSC phenotypes by acting as a sponge of miR-145 in pancreatic cancer cells

Yuran Gao, Zhicheng Zhang, Kai Li, Liying Gong, Qingzhu Yang, Xuemei Huang, Chengcheng Hong, Mingfeng Ding and Huanjie Yang

Cell Death Dis 2017 8: e2924; 10.1038/cddis.2017.311

Abstract | Full Text

Binding of doxorubicin to Sorcin impairs cell death and increases drug resistance in cancer cells

Ilaria Genovese, Annarita Fiorillo, Andrea Ilari, Silvia Masciarelli, Francesco Fazi and Gianni Colotti

Cell Death Dis 2017 8: e2950; 10.1038/cddis.2017.342

Abstract | Full Text

miR-181d and c-myc-mediated inhibition of CRY2 and FBXL3 reprograms metabolism in colorectal cancer

Xiaofeng Guo, Yuekun Zhu, Xinya Hong, Mukun Zhang, Xingfeng Qiu, Zhenfa Wang, Zhongquan Qi and Xuehui Hong

Cell Death Dis 2017 8: e2958; 10.1038/cddis.2017.300

Abstract | Full Text

Neuroprotection by eIF2α-CHOP inhibition and XBP-1 activation in EAE/optic neuritiss

Haoliang Huang, Linqing Miao, Feisi Liang, Xiaodong Liu, Lin Xu, Xiuyin Teng, Qizhao Wang, William H Ridder, III, Kenneth S Shindler, Yang Sun and Yang Hu

Cell Death Dis 2017 8: e2936; 10.1038/cddis.2017.329

Abstract | Full Text

Pleiotropic effects of sphingosine-1-phosphate signaling to control human chorionic mesenchymal stem cell physiology

Giulio Innamorati, Emanuela Fontana, Federica Steccanella, Kushal Gandhi, Giulio Bassi, Valeria Zandonà and Luca Giacomello

Cell Death Dis 2017 8: e2930; 10.1038/cddis.2017.312

Abstract | Full Text

WWOX sensitises ovarian cancer cells to paclitaxel via modulation of the ER stress response

Szymon Janczar, Jaya Nautiyal, Yi Xiao, Edward Curry, Mingjun Sun, Elisa Zanini, Adam JW Paige and Hani Gabra

Cell Death Dis 2017 8: e2955; 10.1038/cddis.2017.346

Abstract | Full Text

An autocrine inflammatory forward-feedback loop after chemotherapy withdrawal facilitates the repopulation of drug-resistant breast cancer cells

Deyong Jia, Li Li, Sulaiman Andrew, David Allan, Xuguang Li, Jonathan Lee, Guang Ji, Zemin Yao, Suresh Gadde, Danial Figeys and Lisheng Wang

Cell Death Dis 2017 8: e2932; 10.1038/cddis.2017.319

Abstract | Full Text

ALKBH7 drives a tissue and sex-specific necrotic cell death response following alkylation-induced damage

Jennifer J Jordan, Sophea Chhim, Carrie M Margulies, Mariacarmela Allocca, Roderick T Bronson, Arne Klungland, Leona D Samson and Dragony Fu

Cell Death Dis 2017 8: e2947; 10.1038/cddis.2017.343

Abstract | Full Text

Platinum pyrithione induces apoptosis in chronic myeloid leukemia cells resistant to imatinib via DUB inhibition-dependent caspase activation and Bcr-Abl downregulation

Xiaoying Lan, Chong Zhao, Xin Chen, Peiquan Zhang, Dan Zang, Jinjie Wu, Jinghong Chen, Huidan Long, Li Yang, Hongbiao Huang, Xuejun Wang, Xianping Shi and Jinbao Liu

Cell Death Dis 2017 8: e2913; 10.1038/cddis.2017.284

Abstract | Full Text

Pre-synaptic TrkB in basolateral amygdala neurons mediates BDNF signaling transmission in memory extinction

Yuan Li, Dongdong Wang, Yang Li, Hongxia Chu, Lining Zhang, Ming Hou, Xingyu Jiang, Zheyu Chen, Bo Su and Tao Sun

Cell Death Dis 2017 8: e2959; 10.1038/cddis.2017.302

Abstract | Full Text

Conservation and divergence of mitochondrial apoptosis pathway in the Pacific oyster, Crassostrea gigas

Yingxiang Li, Linlin Zhang, Tao Qu, Xueying Tang, Li Li and Guofan Zhang

Cell Death Dis 2017 8: e2915; 10.1038/cddis.2017.307

Abstract | Full Text

The EGFR/miR-338-3p/EYA2 axis controls breast tumor growth and lung metastasis

Yingchun Liang, Xiaojie Xu, Tao Wang, Ying Li, Wenye You, Jing Fu, Yang Liu, Shuai Jin, Quanbo Ji, Wei Zhao, Qi Song, Ling Li, Tian Hong, Junjian Huang, Zhaohui Lyu and Qinong Ye

Cell Death Dis 2017 8: e2928; 10.1038/cddis.2017.325

Abstract | Full Text

BAG3 promotes stem cell-like phenotype in breast cancer by upregulation of CXCR4 via interaction with its transcript

Bao-Qin Liu, Song Zhang, Si Li, Ming-Xin An, Chao Li, Jing Yan, Jia-Mei Wang and Hua-Qin Wang

Cell Death Dis 2017 8: e2933; 10.1038/cddis.2017.324

Abstract | Full Text

mTORC2 regulates hedgehog pathway activity by promoting stability to Gli2 protein and its nuclear translocation

Samarpan Maiti, Susmita Mondal, Eswara M Satyavarapu and Chitra Mandal

Cell Death Dis 2017 8: e2926; 10.1038/cddis.2017.296

Abstract | Full Text

Humanin G (HNG) protects age-related macular degeneration (AMD) transmitochondrial ARPE-19 cybrids from mitochondrial and cellular damage

Sonali Nashine, Pinchas Cohen, Marilyn Chwa, Stephanie Lu, Anthony B Nesburn, Baruch D Kuppermann and M Cristina Kenney

Cell Death Dis 2017 8: e2951; 10.1038/cddis.2017.348

Abstract | Full Text

Autophagy inhibition reduces chemoresistance and tumorigenic potential of human ovarian cancer stem cells

Anna Pagotto, Giorgia Pilotto, Elena Laura Mazzoldi, Maria Ornella Nicoletto, Simona Frezzini, Anna Pastò and Alberto Amadori

Cell Death Dis 2017 8: e2943; 10.1038/cddis.2017.327

Abstract | Full Text

p75NTR antagonists attenuate photoreceptor cell loss in murine models of retinitis pigmentosa

María Platón-Corchado, Pablo F Barcelona, Sean Jmaeff, Miguel Marchena, Alberto M Hernández-Pinto, Catalina Hernández-Sánchez, H Uri Saragovi and Enrique J de la Rosa

Cell Death Dis 2017 8: e2922; 10.1038/cddis.2017.306

Abstract | Full Text

Killing two birds with one stone: dual blockade of integrin and FGF signaling through targeting syndecan-4 in postoperative capsular opacification

Yingyan Qin, Yi Zhu, Furong Luo, Chuan Chen, Xiaoyun Chen and Mingxing Wu

Cell Death Dis 2017 8: e2920; 10.1038/cddis.2017.315

Abstract | Full Text

Maml1 acts cooperatively with Gli proteins to regulate sonic hedgehog signaling pathway

Roberta Quaranta, Maria Pelullo, Sabrina Zema, Francesca Nardozza, Saula Checquolo, Dieter Matthias Lauer, Francesca Bufalieri, Rocco Palermo, Maria Pia Felli, Alessandra Vacca, Claudio Talora, Lucia Di Marcotullio, Isabella Screpanti and Diana Bellavia

Cell Death Dis 2017 8: e2942; 10.1038/cddis.2017.326

Abstract | Full Text

T-cell autonomous death induced by regeneration of inert glucocorticoid metabolites

Lourdes Rocamora-Reverte, Holger M Reichardt, Andreas Villunger and GJan Wiegers

Cell Death Dis 2017 8: e2948; 10.1038/cddis.2017.344

Abstract | Full Text

The cohesin complex prevents Myc-induced replication stress

Sara Rohban, Aurora Cerutti, Marco J Morelli, Fabrizio d'Adda di Fagagna and Stefano Campaner

Cell Death Dis 2017 8: e2956; 10.1038/cddis.2017.345

Abstract | Full Text

Sphingosine kinase 2 activates autophagy and protects neurons against ischemic injury through interaction with Bcl-2 via its putative BH3 domain

Dan-Dan Song, Tong-Tong Zhang, Jia-Li Chen, Yun-Fei Xia, Zheng-Hong Qin, Christian Waeber and Rui Sheng

Cell Death Dis 2017 8: e2912; 10.1038/cddis.2017.289

Abstract | Full Text

JUN is important for ocular hypertension-induced retinal ganglion cell degeneration

Stephanie B Syc-Mazurek, Kimberly A Fernandes and Richard T Libby

Cell Death Dis 2017 8: e2945; 10.1038/cddis.2017.338

Abstract | Full Text

Aryl hydrocarbon receptor activation restores filaggrin expression via OVOL1 in atopic dermatitis

Gaku Tsuji, Akiko Hashimoto-Hachiya, Mari Kiyomatsu-Oda, Masaki Takemura, Fumitaka Ohno, Takamichi Ito, Saori Morino-Koga, Chikage Mitoma, Takeshi Nakahara, Hiroshi Uchi and Masutaka Furue

Cell Death Dis 2017 8: e2931; 10.1038/cddis.2017.322

Abstract | Full Text

Interleukin-22 ameliorated renal injury and fibrosis in diabetic nephropathy through inhibition of NLRP3 inflammasome activation

Shaofei Wang, Yubin Li, Jiajun Fan, Xuyao Zhang, Jingyun Luan, Qi Bian, Tao Ding, Yichen Wang, Ziyu Wang, Ping Song, Daxiang Cui, Xiaobin Mei and Dianwen Ju

Cell Death Dis 2017 8: e2937; 10.1038/cddis.2017.292

Abstract | Full Text

FOXQ1 regulates senescence-associated inflammation via activation of SIRT1 expression

Pan Wang, Cuicui Lv, Tao Zhang, Junling Liu, Jin Yang, Fangxia Guan and Tianpei Hong

Cell Death Dis 2017 8: e2946; 10.1038/cddis.2017.340

Abstract | Full Text

Oroxylin A activates PKM1/HNF4 alpha to induce hepatoma differentiation and block cancer progression

Libin Wei, Yuanyuan Dai, Yuxin Zhou, Zihao He, Jingyue Yao, Li Zhao, Qinglong Guo and Lin Yang

Cell Death Dis 2017 8: e2944; 10.1038/cddis.2017.335

Abstract | Full Text

Cytoplasmic fragment of CD147 generated by regulated intramembrane proteolysis contributes to HCC by promoting autophagy

Bo Wu, Jian Cui, Xiang-Min Yang, Zhen-Yu Liu, Fei Song, Ling Li, Jian-Li Jiang and Zhi-Nan Chen

Cell Death Dis 2017 8: e2925; 10.1038/cddis.2017.251

Abstract | Full Text

Retinoic acid-induced upregulation of miR-219 promotes the differentiation of embryonic stem cells into neural cells

Haibo Wu, Jiamin Zhao, Beibei Fu, Songna Yin, Chao Song, Jingcheng Zhang, Shanting Zhao and Yong Zhang

Cell Death Dis 2017 8: e2953; 10.1038/cddis.2017.336

Abstract | Full Text

Knockout of MARCH2 inhibits the growth of HCT116 colon cancer cells by inducing endoplasmic reticulum stress

Dan Xia, Wanli Ji, Chentong Xu, Xin Lin, Xiaokun Wang, Yan Xia, Ping Lv, Quansheng Song, Dalong Ma and Yingyu Chen

Cell Death Dis 2017 8: e2957; 10.1038/cddis.2017.347

Abstract | Full Text

MICU1 protects against myocardial ischemia/reperfusion injury and its control by the importer receptor Tom70

Qiang Xue, Haifeng Pei, Qinshe Liu, Mingjun Zhao, Jing Sun, Erhe Gao, Xinliang Ma and Ling Tao

Cell Death Dis 2017 8: e2923; 10.1038/cddis.2017.280

Abstract | Full Text

Autophagosome maturation mediated by Rab7 contributes to neuroprotection of hypoxic preconditioning against global cerebral ischemia in rats

Lixuan Zhan, Siyuan Chen, Kongping Li, Donghai Liang, Xinyong Zhu, Liu Liu, Zhiwei Lu, Weiwen Sun and En Xu

Cell Death Dis 2017 8: e2949; 10.1038/cddis.2017.330

Abstract | Full Text

KMT2A promotes melanoma cell growth by targeting hTERT signaling pathway

Changlin Zhang, Chen Song, Tianze Liu, Ranran Tang, Miao Chen, Fan Gao, Binyi Xiao, Ge Qin, Fen Shi, Wenbin Li, Yixin Li, Xiaoyan Fu, Dingbo Shi, Xiangsheng Xiao, Lan Kang, Wenlin Huang, Xiaojun Wu, Bing Tang and Wuguo Deng

Cell Death Dis 2017 8: e2940; 10.1038/cddis.2017.285

Abstract | Full Text

Protection of Mcc950 against high-glucose-induced human retinal endothelial cell dysfunction

Yi Zhang, Xuehua Lv, Zizhong Hu, Xiaojian Ye, Xinhua Zheng, Yuzhi Ding, Ping Xie and Qinghuai Liu

Cell Death Dis 2017 8: e2941; 10.1038/cddis.2017.308

Abstract | Full Text

Zinc oxide nanoparticles harness autophagy to induce cell death in lung epithelial cells

Jun Zhang, Xia Qin, Bin Wang, Ge Xu, Zhexue Qin, Jian Wang, Lanxiang Wu, Xiangwu Ju, Diptiman D Bose, Feng Qiu, Honghao Zhou and Zhen Zou

Cell Death Dis 2017 8: e2954; 10.1038/cddis.2017.337

Abstract | Full Text

Keratin 23 promotes telomerase reverse transcriptase expression and human colorectal cancer growth

Ningning Zhang, Rui Zhang, Kun Zou, Wendan Yu, Wei Guo, Yingying Gao, Jia Li, Mei Li, Yidi Tai, Wenlin Huang, Chun Song, Wuguo Deng and Xiaonan Cui

Cell Death Dis 2017 8: e2961; 10.1038/cddis.2017.339

Abstract | Full Text

PKCζ phosphorylates TRAF2 to protect against intestinal ischemia–reperfusion–induced injury

Wei Zhou, Jihong Yao, Guangzhi Wang, Zhao Chen, Zhenlu Li, Dongcheng Feng, Yang Li, Wasim Qasim, Wenzhi Tan, Shili Ning and Xiaofeng Tian

Cell Death Dis 2017 8: e2935; 10.1038/cddis.2017.310

Abstract | Full Text

RIP3 attenuates the pancreatic damage induced by deletion of ATG7

Xiaodong Zhou, Li Xie, Leizhou Xia, Frank Bergmann, Markus W Büchler, Guido Kroemer, Thilo Hackert and Franco Fortunato

Cell Death Dis 2017 8: e2918; 10.1038/cddis.2017.313

Abstract | Full Text

lncRNA MIAT functions as a competing endogenous RNA to upregulate DAPK2 by sponging miR-22-3p in diabetic cardiomyopathy

Xiang Zhou, Wei Zhang, Mengchao Jin, Jianchang Chen, Weiting Xu and Xiangqing Kong

Cell Death Dis 2017 8: e2929; 10.1038/cddis.2017.321

Abstract | Full Text

Calcium-binding protein S100A14 induces differentiation and suppresses metastasis in gastric cancer

Min Zhu, Hongyi Wang, Jiantao Cui, Wenmei Li, Guo An, Yuanming Pan, Qingying Zhang, Rui Xing and Youyong Lu

Cell Death Dis 2017 8: e2938; 10.1038/cddis.2017.297

Abstract | Full Text

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