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Nature Reviews Molecular Cell Biology
May 2018 Volume 19 Number 5 Advertisement
Nature Reviews Molecular Cell Biology cover
2016 2-year Impact Factor 46.602 Journal Metrics 2-year Median 28.5
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Research Highlights
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 Featured article:
Understanding the diversity of membrane lipid composition
Takeshi Harayama & Howard Riezman

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Comment: The future of CRISPR technologies in agriculture
Caixia Gao

p275 | doi:10.1038/nrm.2018.2
Conventional plant breeding is unlikely to meet increasing food demands and other environmental challenges. By contrast, CRISPR technology is erasing barriers to genome editing and could revolutionize plant breeding. However, to fully benefit from the CRISPR revolution, we should focus on resolving its technical and regulatory uncertainties.
Caixia Gao outlines the technical, regulatory and public opinion hurdles for the future use of CRISPR technologies in plant breeding.
Full Text | PDF


Regeneration: Mending broken hearts
p277 | doi:10.1038/nrm.2018.18
The polyploidy of mammalian cardiomyocytes is a barrier to heart regeneration, but modification of the cardiomyocyte cell cycle can boost their regenerative potential.

Reprogramming: Methylation patterns in primordial germ cells
p278 | doi:10.1038/nrm.2018.20
This study describes the molecular mechanisms underlying epigenetic reprogramming in primordial germ cells.

Mechanotransduction: Kindlin' the fate of mesenchymal stem cells
p278 | doi:10.1038/nrm.2018.21
Kindlin-2 controls mesenchymal stem cell differentiation in repsonse to matrix stiffness by regulting the levels and activity of YAP and TAZ.

Cell signalling: DNA damage puts p38 under the UV light
p279 | doi:10.1038/nrm.2018.22
Ultraviolet radiation induces p38-MK2-dependent phosphorylation of NELFE, which causes its dissociation from chromatin and promotes transcription of damage-response genes.


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Nature Index 2018 Japan

Some of Japan's smallest institutions are among the most efficient in the production of high quality scientific research, though the decline in Japan's high quality scientific research output continues. This supplement examines reform efforts in light of the country's aim to become a "super-smart" society.

Read the full supplement
Understanding the diversity of membrane lipid composition
Takeshi Harayama & Howard Riezman

p281 | doi:10.1038/nrm.2017.138
Membrane lipids exhibit a remarkable diversity — they vary in structure and chemical properties, and their distribution between different membranes and their subcompartments is highly heterogeneous. Recent progress in studies of membrane lipids has broadened our understanding of how this diversity affects membrane properties and membrane-associated processes.
Abstract | Full Text | PDF | Supplementary information

Once and only once: mechanisms of centriole duplication and their deregulation in disease
Erich A. Nigg & Andrew J. Holland

p297 | doi:10.1038/nrm.2017.127
Most eukaryotic cells contain a single centrosome with a pair of centrioles, which duplicate before mitosis. Defects in duplication lead to aberrant numbers of centrioles and centrosomes. Recent insights into mechanisms of centriole biogenesis and centriole number control are helping us to better understand the links between aberrant centrosome number and human disease.
Abstract | Full Text | PDF

Mechanisms of clathrin-mediated endocytosis
Marko Kaksonen & Aurélien Roux

p313 | doi:10.1038/nrm.2017.132
Clathrin-mediated endocytosis is the main mechanism for internalization of cell-surface molecules and surface-bound cargoes. Although the machineries that drive the formation of endocytic vesicle are intricate, an understanding of endocytosis is being unravelled at the molecular level.
Abstract | Full Text | PDF

A brave new world of RNA-binding proteins
Matthias W. Hentze, Alfredo Castello, Thomas Schwarzl & Thomas Preiss

p327 | doi:10.1038/nrm.2017.130
Recent proteome-wide studies have uncovered hundreds of RNA-binding proteins (RBPs) that lack conventional RNA-binding domains. These RBPs instead use intrinsically disordered regions, protein-protein interaction interfaces and enzymatic cores to bind RNA. Interestingly, some RBPs are regulated by RNA rather than regulate RNA.
Abstract | Full Text | PDF | Supplementary information

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