If you are still having problems viewing this message, please click here for additional help.

Nature Reviews Molecular Cell Biology
 
TABLE OF CONTENTS
 
May 2018 Volume 19 Number 5 Advertisement
 
Nature Reviews Molecular Cell Biology cover
2016 2-year Impact Factor 46.602 Journal Metrics 2-year Median 28.5
In this issue
Comment
Research Highlights
Reviews
 
Also this month
 Featured article:
Understanding the diversity of membrane lipid composition
Takeshi Harayama & Howard Riezman

 
Nominations now open!

Who are the future leading women in science? The Nature Research Awards for Inspiring Science and Innovating Science are now open for nominations.

Find out more about these awards and nominate your inspiration

In partnership with The Estée Lauder Companies.

 
Subscribe
 
Facebook
 
RSS
 
Recommend to library
 
Twitter
   
Advertisement
Nature Outlook: Cancer immunotherapy 

Drugs that mobilize our immune systems against cancer are dramatically improving care for many people, and research is rapidly moving ahead in the lab and the clinic. 

Access this Outlook free online for more 

Produced with support from 
F. Hoffmann-La Roche Ltd  
Medimmune 
Produced with support of a grant from Merck & Co., Inc.
 
Comment: The future of CRISPR technologies in agriculture
Caixia Gao

p275 | doi:10.1038/nrm.2018.2
Conventional plant breeding is unlikely to meet increasing food demands and other environmental challenges. By contrast, CRISPR technology is erasing barriers to genome editing and could revolutionize plant breeding. However, to fully benefit from the CRISPR revolution, we should focus on resolving its technical and regulatory uncertainties.
Caixia Gao outlines the technical, regulatory and public opinion hurdles for the future use of CRISPR technologies in plant breeding.
Full Text | PDF

 
RESEARCH HIGHLIGHTS
 
Top

Regeneration: Mending broken hearts
p277 | doi:10.1038/nrm.2018.18
The polyploidy of mammalian cardiomyocytes is a barrier to heart regeneration, but modification of the cardiomyocyte cell cycle can boost their regenerative potential.
PDF


Reprogramming: Methylation patterns in primordial germ cells
p278 | doi:10.1038/nrm.2018.20
This study describes the molecular mechanisms underlying epigenetic reprogramming in primordial germ cells.
PDF


Mechanotransduction: Kindlin' the fate of mesenchymal stem cells
p278 | doi:10.1038/nrm.2018.21
Kindlin-2 controls mesenchymal stem cell differentiation in repsonse to matrix stiffness by regulting the levels and activity of YAP and TAZ.
PDF


Cell signalling: DNA damage puts p38 under the UV light
p279 | doi:10.1038/nrm.2018.22
Ultraviolet radiation induces p38-MK2-dependent phosphorylation of NELFE, which causes its dissociation from chromatin and promotes transcription of damage-response genes.
PDF


 

Nature Reviews Molecular Cell Biology
JOBS of the week
Research group leader (2 positions)
Centre of New Technologies, University of Warsaw
Postdoctoral fellow
Institute of Oncology Research (IOR) - An Institute affiliated to USI - Universit� della Svizzera italiana
Post-doctoral Associate
Yale University School of Medicine
Senior Project Manager
University of Glasgow
Post-Doctoral Fellow
Johns Hopkins University
More Science jobs from
Nature Reviews Molecular Cell Biology
EVENT
Single Cell Technologies and Analysis
21.07.18
Hinxton, UK
More science events from
Advertisement
Nature Index 2018 Japan

Some of Japan's smallest institutions are among the most efficient in the production of high quality scientific research, though the decline in Japan's high quality scientific research output continues. This supplement examines reform efforts in light of the country's aim to become a "super-smart" society.

Read the full supplement
 
 
REVIEWS
 
Top
Understanding the diversity of membrane lipid composition
Takeshi Harayama & Howard Riezman

p281 | doi:10.1038/nrm.2017.138
Membrane lipids exhibit a remarkable diversity — they vary in structure and chemical properties, and their distribution between different membranes and their subcompartments is highly heterogeneous. Recent progress in studies of membrane lipids has broadened our understanding of how this diversity affects membrane properties and membrane-associated processes.
Abstract | Full Text | PDF | Supplementary information

 
Once and only once: mechanisms of centriole duplication and their deregulation in disease
Erich A. Nigg & Andrew J. Holland

p297 | doi:10.1038/nrm.2017.127
Most eukaryotic cells contain a single centrosome with a pair of centrioles, which duplicate before mitosis. Defects in duplication lead to aberrant numbers of centrioles and centrosomes. Recent insights into mechanisms of centriole biogenesis and centriole number control are helping us to better understand the links between aberrant centrosome number and human disease.
Abstract | Full Text | PDF

 
Mechanisms of clathrin-mediated endocytosis
Marko Kaksonen & Aurélien Roux

p313 | doi:10.1038/nrm.2017.132
Clathrin-mediated endocytosis is the main mechanism for internalization of cell-surface molecules and surface-bound cargoes. Although the machineries that drive the formation of endocytic vesicle are intricate, an understanding of endocytosis is being unravelled at the molecular level.
Abstract | Full Text | PDF

 
A brave new world of RNA-binding proteins
Matthias W. Hentze, Alfredo Castello, Thomas Schwarzl & Thomas Preiss

p327 | doi:10.1038/nrm.2017.130
Recent proteome-wide studies have uncovered hundreds of RNA-binding proteins (RBPs) that lack conventional RNA-binding domains. These RBPs instead use intrinsically disordered regions, protein-protein interaction interfaces and enzymatic cores to bind RNA. Interestingly, some RBPs are regulated by RNA rather than regulate RNA.
Abstract | Full Text | PDF | Supplementary information

 
Advertisement
Do you have a career question?

The Naturejobs podcast features one-on-one Q&As, panel discussions and other exclusive content to help scientists with their careers. Hosted on the Naturejobs blog, the podcast is also available on iTunes and Soundcloud. 

Listen today! 
nature events
Natureevents is a fully searchable, multi-disciplinary database designed to maximise exposure for events organisers. The contents of the Natureevents Directory are now live. The digital version is available here.

Find the latest scientific conferences, courses, meetings and symposia on natureevents.com. For event advertising opportunities across the Nature Publishing Group portfolio please contact natureevents@nature.com
More Nature Events

You have been sent this Table of Contents Alert because you have opted in to receive it. You can change or discontinue your e-mail alerts at any time, by modifying your preferences on your nature.com account at: www.nature.com/myaccount
(You will need to log in to be recognised as a nature.com registrant).

For further technical assistance, please contact our registration department

For print subscription enquiries, please contact our subscription department

For other enquiries, please contact our feedback department

Springer Nature | One New York Plaza, Suite 4500 | New York | NY 10004-1562 | USA

Springer Nature's worldwide offices:
London - Paris - Munich - New Delhi - Tokyo - Melbourne
San Diego - San Francisco - Washington - New York - Boston

Macmillan Publishers Limited is a company incorporated in England and Wales under company number 785998 and whose registered office is located at The Campus, 4 Crinan Street, London, N1 9XW.

© 2018 Macmillan Publishers Limited, part of Springer Nature. All Rights Reserved.

Springer Nature