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Nature Reviews Cancer


Discover the strengths and limitations of human immune system-engrafted mice and understand how choosing the right model is critical to effective preclinical immuno-oncology efforts.

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May 2018 Volume 18, Issue 5

Research Highlights

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Metabolic reprogramming is a critical area of research and potential therapeutic strategy for cutaneous squamous cell carcinoma. Learn how the new, quantitative Agilent Seahorse XF Glycolytic Rate Assay can be used for cancer drug screening and to reveal mechanisms of action.

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Nature Milestone: Anticoagulants from Nature Reviews Cardiology 

This Milestone plots the history of anticoagulant drugs, used to prevent and treat thrombotic disorders in millions of patients worldwide. Fourteen Milestone articles are presented on an interactive timeline with associated multimedia. 

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Research Highlights


Breast cancer: Obesity � tipping the scales of resistance    p265
Conor A. Bradley
Using clinical tissue specimens and mouse models of breast cancer, Incio et al. show that obesity promotes the upregulation of interleukin-6 and fibroblast growth factor 2 in the tumour microenvironment, which confer resistance to anti-vascular endothelial growth factor therapy.

Leukaemia: Powers of prediction    pp372 - 373
Anna Dart
Good et al. use deep phenotypic single-cell analyses and machine learning to identify developmentally dependent cell signalling states in B cell precursor acute lymphoblastic leukaemia that are predictive of relapse.

Breast cancer: External communication    pp372 - 373
Ulrike Harjes
In a new study, researchers show that basal-like breast cancer can be converted into the luminal subtype by inhibiting platelet-derived growth factor (PDGF)-CC signalling in the tumour microenvironment, thereby potentially broadening treatment options for oestrogen receptor-negative breast cancer patients.

Pancreatic cancer: The COMPASS shows the way    p373
Sarah Seton-Rogers
Deregulation of the COMPASS-like complex, via loss of KDM6A in females and loss of both KDM6A and its Y chromosome homologue UTY in males, is important for activation of oncogene-associated super-enhancers and the development of pancreatic adenocarcinoma of the squamous subtype.

Nature Reviews Cancer
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The molecular landscape of head and neck cancer    pp269 - 282
C. René Leemans, Peter J. F. Snijders & Ruud H. Brakenhoff
Head and neck cancer is an unexpectedly heterogeneous disease. In this Review, Leemans, Snijders and Brakenhoff provide an update on the molecular biology of head and neck cancer, outline the role of human papillomavirus and discuss the functional role of genes involved in malignant progression to identify subgroups to personalize treatment.

Gut microbiota injury in allogeneic haematopoietic stem cell transplantation    pp283 - 295
Yusuke Shono & Marcel R. M. van den Brink
Allogeneic haematopoietic stem cell transplantation (allo-HSCT) is a well-established treatment for many haematopoietic malignancies but often results in life-threatening complications, such as graft-versus-host disease, relapse and infections. This Review discusses the potential role of intestinal microbiota in complications after allo-HSCT.

Cell motility in cancer invasion and metastasis: insights from simple model organisms    pp296 - 312
Christina H. Stuelten, Carole A. Parent & Denise J. Montell
In this Review, Stuelten et al. outline insights with relevance to human cancer invasion and metastasis that have come from the study of cell motility in non-mammalian model organisms.

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Using immunotherapy to boost the abscopal effect    pp313 - 322
Wilfred Ngwa, Omoruyi Credit Irabor, Jonathan D. Schoenfeld, Jürgen Hesser, Sandra Demaria et al.
The abscopal effect, which is the regression of metastatic cancer at distant sites during radiotherapy, is somewhat rare but can be promoted by immunotherapy. This Opinion article describes emerging concepts and limitations of using a combination of radiotherapy and immunotherapy to boost the abscopal effect.

Non-angiogenic tumours and their influence on cancer biology    pp323 - 336
Tom Donnem, Andrew R. Reynolds, Elizabeth A. Kuczynski, Kevin Gatter, Peter B. Vermeulen et al.
In this Opinion article, Donnem et al. outline the evidence for non-angiogenic tumours, which use pre-existing blood vessels to support tumour growth, and discuss the studies that are beginning to define their unique biology.

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