If you are still having problems viewing this message, please click here for additional help.

Nature Reviews Immunology

Real time detection of neutrophil activation

Discover a new method to assess neutrophil activation and oxidative burst with Agilent Seahorse XF technology. Simultaneous glycolytic (PER) and oxygen consumption (OCR) rate detection can dissect the interdependency of the two pathways that are required for neutrophil activation.

Download the app note to learn more.

May 2018 Volume 18, Issue 5

Research Highlights

nature.com webcasts
Nature Research Custom presents a webcast on: Ultra-sensitive detection of interferon alpha protein in human disease by digital ELISA
Date: Tuesday, May 15, 2018
Darragh Duffy, Institut Pasteur, will address how digital ELISA enables direct qualification of IFNa protein in human samples. This webcast has been produced on behalf of the sponsor who retains sole responsibility for content
Sponsored by: Quanterix

Nature Roundtable: The Future of Medicine, 16 July, 2018 | Darmstadt, Germany

In association with the Curious2018 - Future Insight Conference, Nature and Nature Medicine have invited outstanding researchers in academia and industry for a round table discussion of the most exciting scientific developments that are shaping the future of medicine. Discover more and apply for your free ticket.


Do you have a career question?

The Naturejobs podcast features one-on-one Q&As, panel discussions and other exclusive content to help scientists with their careers. Hosted on the Naturejobs blog, the podcast is also available on iTunes and Soundcloud. 

Listen today!



Discovering transcriptional signatures of disease for diagnosis versus mechanism    pp289 - 290
Julie G. Burel & Bjoern Peters

Research Highlights


Mucosal immunology: Glucose not good for the gut    p291
Kirsty Minton
Hyperglycaemia directly mediates dysfunction of the intestinal epithelial barrier in obesity, leading to increased translocation of microbial products.

Germinal centres: An exit strategy for B cells    pp292 - 293
Kirsty Minton
The ubiquitin ligase activity of CBL proteins controls the exit of B cells from the germinal centre to become plasma cells.

Macrophages: Running on empty    pp292 - 293
Yvonne Bordon
NRP1-deficient macrophages show impaired fatty acid oxidation.

Allergy: An alarmin cut    p293
Lucy Bird
Proteolytic cleavage of IL-33 by environmental allergens induces rapid induction of allergic type 2 inflammation.

Immunometabolism: Itaconate helps KEAP1's cool    pp294 - 295
Grant Otto
Itaconate alkylates KEAP1 to regulate NRF2 activity and induce an anti-inflammatory response in macrophages

Journal Club

Adaptive immunity by convergent evolution    p294
Jean-Laurent Casanova
Jean-Laurent Casanova describes three papers by Max Cooper and colleagues that described the convergent evolution of adaptive immunity in jawless vertebrates.

Influenza virus: Choose your enemies wisely    pp294 - 295
Yvonne Bordon
Natural influenza virus infection in humans induces protective neuraminidase-reactive antibodies that are not induced by current influenza vaccines.

Immunometabolism: Old drug, new trick    p295
Yvonne Bordon
The immunomodulatory drug dimethyl fumarate blocks GAPDH and aerobic glycolysis in activated immune cells.

Nature Reviews Immunology
JOBS of the week
Malaria Pathogenesis and Immunity Postdoctoral Scientist
National Institute of Allergy and Infectious Diseases
Executive Director, Brown Center for Immunotherapy
Indiana University School of Medicine
University Professor of Immunogerontology
University of Innsbruck
Postdoctoral Position - Immune Oncology
H. Lee Moffitt Cancer & Research Institute
Scientist I / II, Immunology
More Science jobs from
Nature Reviews Immunology
Nutritional Immunology and the Microbiota: Rules of Engagement in Health and Disease
Leesburg, USA
More science events from



Passive immunotherapy of viral infections: 'super-antibodies' enter the fray    pp297 - 308
Laura M. Walker & Dennis R. Burton
So-called super-antibodies are highly potent, broadly reactive antiviral antibodies that offer promise for the treatment of various chronic and emerging viruses. This Review describes how recent technological advances led to their isolation from rare, infected individuals and their development for the prevention and treatment of various viral infections.

NF-κB, inflammation, immunity and cancer: coming of age    pp309 - 324
Koji Taniguchi & Michael Karin
Here, Koji Taniguchi and Michael Karin discuss the key roles of the nuclear factor-κB (NF-κB) transcription factor in cancer-related inflammation and consider the potential of targeting NF-κB in different types of cancer.

HLA variation and disease    pp325 - 339
Calliope A. Dendrou, Jan Petersen, Jamie Rossjohn & Lars Fugger
Technological advances have given valuable insight into the molecular mechanisms that underpin the association between HLA genetics and disease. Dendrou and colleagues review mechanisms of HLA–peptide–T cell receptor binding in health and disease and discuss how this knowledge may be translated into clinical benefit.

Epigenetic control of CD8+ T cell differentiation    pp340 - 356
Amanda N. Henning, Rahul Roychoudhuri & Nicholas P. Restifo
CD8+ T cell differentiation and function are regulated by epigenetic changes mainly including DNA methylation, histone modification and modification of chromatin architecture. As described here, a detailed understanding of these epigenetic mechanisms can be harnessed to improve T cell-based immunotherapies.

Searching for a new career? 

At Nature Research we frequently recruit talented individuals to join our editorial and publishing teams. If you have a PhD and a passion for science this may be the perfect career for you.

Visit our research editorial and publishing careers website to discover more about what we do 
nature events
Natureevents is a fully searchable, multi-disciplinary database designed to maximise exposure for events organisers. The contents of the Natureevents Directory are now live. The digital version is available here.
Find the latest scientific conferences, courses, meetings and symposia on natureevents.com. For event advertising opportunities across the Nature Publishing Group portfolio please contact natureevents@nature.com
More Nature Events

You have been sent this Table of Contents Alert because you have opted in to receive it. You can change or discontinue your e-mail alerts at any time, by modifying your preferences on your nature.com account at: www.nature.com/myaccount
(You will need to log in to be recognised as a nature.com registrant)

For further technical assistance, please contact our registration department

For print subscription enquiries, please contact our subscription department

For other enquiries, please contact our customer feedback department

Springer Nature | One New York Plaza, Suite 4500 | New York | NY 10004-1562 | USA

Springer Nature's worldwide offices:
London - Paris - Munich - New Delhi - Tokyo - Melbourne
San Diego - San Francisco - Washington - New York - Boston

Macmillan Publishers Limited is a company incorporated in England and Wales under company number 785998 and whose registered office is located at The Campus, 4 Crinan Street, London, N1 9XW.

© 2018 Macmillan Publishers Limited, part of Springer Nature. All Rights Reserved.

Springer Nature