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Nature Reviews Immunology

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TABLE OF CONTENTS

May 2018 Volume 18, Issue 5

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Research Highlights
Reviews
 
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Discovering transcriptional signatures of disease for diagnosis versus mechanism    pp289 - 290
Julie G. Burel & Bjoern Peters
doi:10.1038/nri.2018.26

Research Highlights

 

Mucosal immunology: Glucose not good for the gut    p291
Kirsty Minton
doi:10.1038/nri.2018.22
Hyperglycaemia directly mediates dysfunction of the intestinal epithelial barrier in obesity, leading to increased translocation of microbial products.

Germinal centres: An exit strategy for B cells    pp292 - 293
Kirsty Minton
doi:10.1038/nri.2018.24
The ubiquitin ligase activity of CBL proteins controls the exit of B cells from the germinal centre to become plasma cells.

Macrophages: Running on empty    pp292 - 293
Yvonne Bordon
doi:10.1038/nri.2018.25
NRP1-deficient macrophages show impaired fatty acid oxidation.

Allergy: An alarmin cut    p293
Lucy Bird
doi:10.1038/nri.2018.23
Proteolytic cleavage of IL-33 by environmental allergens induces rapid induction of allergic type 2 inflammation.

Immunometabolism: Itaconate helps KEAP1's cool    pp294 - 295
Grant Otto
doi:10.1038/nri.2018.27
Itaconate alkylates KEAP1 to regulate NRF2 activity and induce an anti-inflammatory response in macrophages

Journal Club

Adaptive immunity by convergent evolution    p294
Jean-Laurent Casanova
doi:10.1038/nri.2018.28
Jean-Laurent Casanova describes three papers by Max Cooper and colleagues that described the convergent evolution of adaptive immunity in jawless vertebrates.

Influenza virus: Choose your enemies wisely    pp294 - 295
Yvonne Bordon
doi:10.1038/nri.2018.30
Natural influenza virus infection in humans induces protective neuraminidase-reactive antibodies that are not induced by current influenza vaccines.

Immunometabolism: Old drug, new trick    p295
Yvonne Bordon
doi:10.1038/nri.2018.29
The immunomodulatory drug dimethyl fumarate blocks GAPDH and aerobic glycolysis in activated immune cells.

Nature Reviews Immunology
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Reviews

 

Passive immunotherapy of viral infections: 'super-antibodies' enter the fray    pp297 - 308
Laura M. Walker & Dennis R. Burton
doi:10.1038/nri.2017.148
So-called super-antibodies are highly potent, broadly reactive antiviral antibodies that offer promise for the treatment of various chronic and emerging viruses. This Review describes how recent technological advances led to their isolation from rare, infected individuals and their development for the prevention and treatment of various viral infections.

NF-κB, inflammation, immunity and cancer: coming of age    pp309 - 324
Koji Taniguchi & Michael Karin
doi:10.1038/nri.2017.142
Here, Koji Taniguchi and Michael Karin discuss the key roles of the nuclear factor-κB (NF-κB) transcription factor in cancer-related inflammation and consider the potential of targeting NF-κB in different types of cancer.

HLA variation and disease    pp325 - 339
Calliope A. Dendrou, Jan Petersen, Jamie Rossjohn & Lars Fugger
doi:10.1038/nri.2017.143
Technological advances have given valuable insight into the molecular mechanisms that underpin the association between HLA genetics and disease. Dendrou and colleagues review mechanisms of HLA–peptide–T cell receptor binding in health and disease and discuss how this knowledge may be translated into clinical benefit.

Epigenetic control of CD8+ T cell differentiation    pp340 - 356
Amanda N. Henning, Rahul Roychoudhuri & Nicholas P. Restifo
doi:10.1038/nri.2017.146
CD8+ T cell differentiation and function are regulated by epigenetic changes mainly including DNA methylation, histone modification and modification of chromatin architecture. As described here, a detailed understanding of these epigenetic mechanisms can be harnessed to improve T cell-based immunotherapies.

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