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May 2018 Volume 20, Issue 5

News & Views

T cell flow cytometry training course (June 27–28, 2018)

This 2-day hands-on training course at Miltenyi Biotec/Germany focusses on the detection and analysis of antigen-specific human T cell subsets. Combining lectures and practical lab sessions, methods covering rare cell analysis and flow cytometric characterization of T cell populations will be introduced.



Methodical about Methods    p505

News & Views


MYC sets a tumour-stroma metabolic loop    pp506 - 507
Hilary A. Coller

XMAP215 joins microtubule nucleation team    pp508 - 510
Jens Lüders

Mitochondrial OXPHOS complex assembly lines    pp511 - 513
Luke E. Formosa & Michael T. Ryan

Brd4-independence in ground state pluripotency    pp513 - 515
Yaser Atlasi & Hendrik G. Stunnenberg

Nature Cell Biology
JOBS of the week
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St. Jude Children's Research Hospital (SJCRH), Department of Surgery
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Dissecting the roles of miR-140 and its host gene    pp516 - 518
Masafumi Inui, Sho Mokuda, Tempei Sato, Moe Tamano, Shuji Takada et al.

Reply to 'Dissecting the role of miR-140 and its host gene'    pp519 - 520
Weiguo Zou, Rui Shao & Dallas Jones



A brief history of autophagy from cell biology to physiology and disease    pp521 - 527
Noboru Mizushima

A history of autophagy. In this Perspective, Mizushima describes the leaps and bounds in the history of autophagy and discusses unanswered questions driving the field forward.




Spatial orchestration of mitochondrial translation and OXPHOS complex assembly    pp528 - 534
Stefan Stoldt, Dirk Wenzel, Kirsten Kehrein, Dietmar Riedel, Martin Ott et al.

Using super-resolution microscopy and cryo-electron microscopy, Stoldt et al. show that mitochondrial transcript translation and OXPHOS complex assembly are spatially partitioned within the mitochondrial membrane.


Dnmt2 mediates intergenerational transmission of paternally acquired metabolic disorders through sperm small non-coding RNAs    pp535 - 540
Yunfang Zhang, Xudong Zhang, Junchao Shi, Francesca Tuorto, Xin Li et al.

Zhang et al. report that tRNA methyltransferase Dnmt2 is required for sperm small-non-coding-RNA-mediated transmission of paternal metabolic disorders to the offspring.




Counter-rotational cell flows drive morphological and cell fate asymmetries in mammalian hair follicles    pp541 - 552
Maureen Cetera, Liliya Leybova, Bradley Joyce & Danelle Devenport

Cetera et al. show that hair follicle development is characterised by counter-rotational cell rearrangements, which depend on myosin and Shh signalling, and direct cell fate asymmetry.


TFAP2C regulates transcription in human naive pluripotency by opening enhancers    pp553 - 564
William A. Pastor, Wanlu Liu, Di Chen, Jamie Ho, Rachel Kim et al.

Pastor et al. demonstrate a role for TFAP2C in the promotion and maintenance of human naive pluripotency by facilitating the opening of enhancers close to pluripotency factors.


Pluripotency transcription factors and Tet1/2 maintain Brd4-independent stem cell identity    pp565 - 574
Lydia W. S. Finley, Santosha A. Vardhana, Bryce W. Carey, Direna Alonso-Curbelo, Richard Koche et al.

Finley et al. show that Brd4 is dispensable for self-renewal and pluripotency in murine embryonic stem cells (ESCs). In metastable ESCs, Brd4 independence can be achieved by increasing the expression of the pluripotency transcription factors Oct4, Sox2 and Nanog as long as Tet1/2 are present.


XMAP215 is a microtubule nucleation factor that functions synergistically with the γ-tubulin ring complex    pp575 - 585
Akanksha Thawani, Rachel S. Kadzik & Sabine Petry

Thawani et al. show that XMAP215, a microtubule polymerase, acts together with the γ-tubulin ring complex (γ-TuRC) to nucleate microtubules in Xenopus extracts and in vitro, challenging the view that γ-TuRC alone is the universal nucleator.


Loss of KLHL6 promotes diffuse large B-cell lymphoma growth and survival by stabilizing the mRNA decay factor roquin2    pp586 - 596
Jaewoo Choi, Kyutae Lee, Kristin Ingvarsdottir, Roberto Bonasio, Anita Saraf et al.

Choi et al. find that KLHL6, which is mutated in diffuse large B-cell lymphoma, is part of a ubiquitin ligase complex that targets the mRNA decay factor roquin2 for degradation and that loss of KLHL6 enhances cell survival through loss of TNFAIP3.


Cancer-cell-secreted exosomal miR-105 promotes tumour growth through the MYC-dependent metabolic reprogramming of stromal cells    pp597 - 609
Wei Yan, Xiwei Wu, Weiying Zhou, Miranda Y. Fong, Minghui Cao et al.

Consistent crosstalk between cancer cells and stromal cells exists in the tumour microenvironment. Yan et al. show that exosomal miR-105 derived from cancer cells confers metabolic plasticity in recipient cancer-associated fibroblasts to adapt to nutrient-replete and -deplete conditions, thereby sustaining tumour growth.




Defining essential genes for human pluripotent stem cells by CRISPR–Cas9 screening in haploid cells    pp610 - 619


Yilmaz et al. generate a genome-wide loss-of-function library using human haploid embryonic stem cells and define genes that are essential for cell survival, growth and pluripotency maintenance, as well as growth-restricting genes.


Reprogramming of H3K9me3-dependent heterochromatin during mammalian embryo development    pp620 - 631
Chenfei Wang, Xiaoyu Liu, Yawei Gao, Lei Yang, Chong Li et al.

Gao and colleagues characterize genome-wide H3K9me3 distributions in pre- and post-implantation mouse embryos, providing a resource to further our understanding of epigenomic dynamics during mammalian embryogenesis.


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