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TABLE OF CONTENTS

June 2018 Volume 19, Issue 6

Research Highlights
Reviews
 
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Research Highlights

 

Tracing cell-lineage histories    p327
Darren J. Burgess
doi:10.1038/s41576-018-0015-0

Three new studies in Nature and Nature Biotechnology report methods for dissecting transcriptomic cell phenotypes and lineage history simultaneously by combining single-cell RNA sequencing (scRNA-seq) with CRISPR-based lineage tracing.

 

Linking tissues to disease    p328
Ross Cloney
doi:10.1038/s41576-018-0009-y

A recent analysis in Nature Genetics combines genome-wide association study summary statistics with gene expression data to identify the contribution of different cell types and tissues to disease.

 

Taking aim at transcriptional regulator targets    p328
Linda Koch
doi:10.1038/s41576-018-0010-5

A paper in Science reports a strategy that combines rapid chemical-genetic perturbation with measurements of immediate gene expression changes to identify targets of transcriptional regulators.

 

Genetics
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Faculty Positions in Statistical Genetics and Computational Genomics
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Reviews

 

Piercing the dark matter: bioinformatics of long-range sequencing and mapping    pp329 - 346
Fritz J. Sedlazeck, Hayan Lee, Charlotte A. Darby & Michael C. Schatz
doi:10.1038/s41576-018-0003-4

Various genomics-related fields are increasingly taking advantage of long-read sequencing and long-range mapping technologies, but making sense of the data requires new analysis strategies. This Review discusses bioinformatics tools that have been devised to handle the numerous characteristic features of these long-range data types, with applications in genome assembly, genetic variant detection, haplotype phasing, transcriptomics and epigenomics.

 

The genetics of fruit flavour preferences    pp347 - 356
Harry J. Klee & Denise M. Tieman
doi:10.1038/s41576-018-0002-5

Fruit flavour is a complex phenotype that has been adversely affected by human intervention. Recent progress in defining the chemistry of consumer preferences and the availability of high-quality genome sequences are providing a foundation for defining the genetics underlying this trait and could be used for flavour improvement.

 

High-throughput mouse phenomics for characterizing mammalian gene function    pp357 - 370
Steve D. M. Brown, Chris C. Holmes, Ann-Marie Mallon, Terrence F. Meehan, Damian Smedley & Sara Wells
doi:10.1038/s41576-018-0005-2

DNA methylation-based biomarkers and the epigenetic clock theory of ageing    pp371 - 384
Steve Horvath & Kenneth Raj
doi:10.1038/s41576-018-0004-3

Biomarkers of ageing based on DNA methylation data enable accurate age estimates for any tissue across the entire life course. Horvath and Raj review the development of these 'epigenetic clocks' and how they link to biological ageing.

 

Molecular mechanisms driving transcriptional stress responses    pp385 - 397
Anniina Vihervaara, Fabiana M. Duarte & John T. Lis
doi:10.1038/s41576-018-0001-6

Recent studies have revealed the genome-wide reprogramming of gene expression upon exposure to stress, such as acute heat stress. Here, the authors review the molecular mechanisms that underlie stress-induced changes at promoters, enhancers and untranscribed loci.

 

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