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Nature Reviews Cancer

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TABLE OF CONTENTS

June 2018 Volume 18, Issue 6

Research Highlights
Reviews
Perspectives
 
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Research Highlights

 

Take a left here    p337
Anna Dart
doi:10.1038/s41568-018-0011-x

Whether lymph node metastases can be a source of cancer cells for distant metastases has been debated. Now, two studies have used mouse models to show that tumour cells can colonize distant organs by invading lymph node blood vessels.

 

Pap seeking new challenges    pp338 - 339
Ulrike Harjes
doi:10.1038/s41568-018-0013-8

Wang et al. have developed a diagnostic tool (based on the widely used Papanicolaou (Pap) test) to detect endometrial and ovarian cancer in patients by using PCR-based analyses of genetic mutations and aneuploidy.

 

Stop the shedding    pp338 - 339
Sarah Seton-Rogers
doi:10.1038/s41568-018-0012-9

Ferrari de Andrade et al. find that monoclonal antibodies that prevent shedding of MICA and MICB from tumour cells can restore antitumour immunity by natural killer cells.

 

Cell genesis    p339
Anna Dart
doi:10.1038/s41568-018-0014-7

Han et al. have identified a new tumour-induced immune cell population in the spleen that can promote tumour growth through production of the neurotrophic factor artemin.

 

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Reviews

 

Known and novel roles of the MET oncogene in cancer: a coherent approach to targeted therapy    pp341 - 358
Paolo M. Comoglio, Livio Trusolino & Carla Boccaccio
doi:10.1038/s41568-018-0002-y

The MET oncogene encodes a receptor tyrosine kinase with pleiotropic functions. In this Review, Comoglio et al. describe the known and novel MET-mediated biological responses in cancer and discuss how clinical trials testing anti-MET therapies should be designed with careful consideration of these oncogenic functions of MET.

 

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Perspectives

 

A history of exploring cancer in context    pp359 - 376
Shelly Maman & Isaac P. Witz
doi:10.1038/s41568-018-0006-7

In this Timeline article, Maman and Witz describe how much progress has been made in understanding how the tumour microenvironment influences tumour progression since its initial description, highlighting the controversies in the field and the potential of targeting components of the microenvironment for cancer therapy.

 

Structural underpinnings of oestrogen receptor mutations in endocrine therapy resistance    pp377 - 388
John A. Katzenellenbogen, Christopher G. Mayne, Benita S. Katzenellenbogen, Geoffrey L. Greene & Sarat Chandarlapaty
doi:10.1038/s41568-018-0001-z

This Opinion article highlights how activating mutations in the gene encoding oestrogen receptor-α (ERα), a major driver in breast cancer, undermine structural features of wild-type ERα that maintain the ‘off-state’ in the absence of oestrogens, thus making ERα constitutively active and endocrine-therapy resistant.

 

Too many targets, not enough patients: rethinking neuroblastoma clinical trials    pp389 - 400
Jamie I. Fletcher, David S. Ziegler, Toby N. Trahair, Glenn M. Marshall, Michelle Haber et al.
doi:10.1038/s41568-018-0003-x

This Perspective provides an update on targeted therapy development for neuroblastoma and proposes that clinical trial design needs to be rethought in order to provide rigorous, evidence-based assessment of these new therapies in this rare and often deadly paediatric tumour.

 

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