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Nature Reviews Cancer

Visualize and Quantify Cellular Interactions in the Tumor Microenvironment

What would it mean to your research if you could accurately quantify cellular interactions in the tumor microenvironment? Download the eBook to learn how scientists are using the Phenoptics™ research solution to visualize, analyze, quantify and phenotype immune cells in situ, in FFPE tissue sections and TMAs.

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June 2018 Volume 18, Issue 6

Research Highlights

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New Whitepapers: How 3D Models Facilitate Studying Hypoxia in Cancer

Model systems are critical to elucidating molecular pathways underscoring cellular responses to hypoxia. Compared to monolayer cultures, 3D models better replicate the in vivo tumor conditions but which model is best suited for your experiment? Learn more about Cellular Adaptations and Experimental Models
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Research Highlights


Take a left here    p337
Anna Dart

Whether lymph node metastases can be a source of cancer cells for distant metastases has been debated. Now, two studies have used mouse models to show that tumour cells can colonize distant organs by invading lymph node blood vessels.


Pap seeking new challenges    pp338 - 339
Ulrike Harjes

Wang et al. have developed a diagnostic tool (based on the widely used Papanicolaou (Pap) test) to detect endometrial and ovarian cancer in patients by using PCR-based analyses of genetic mutations and aneuploidy.


Stop the shedding    pp338 - 339
Sarah Seton-Rogers

Ferrari de Andrade et al. find that monoclonal antibodies that prevent shedding of MICA and MICB from tumour cells can restore antitumour immunity by natural killer cells.


Cell genesis    p339
Anna Dart

Han et al. have identified a new tumour-induced immune cell population in the spleen that can promote tumour growth through production of the neurotrophic factor artemin.


Nature Reviews Cancer
JOBS of the week
Academic Position in Cancer Research
Cedars Sinai Medical Center
Postdoctoral Research Associate-Stem Cell and Cancer Biology
University of North Texas Health Science Center
Executive Director, Cancer Research
Peter MacCallum Cancer Centre
Junior Health and Research Officer
ECPC - European Cancer Patient Coalition
PhD Student
German Cancer Research Center (DKFZ).
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Nature Reviews Cancer
Origins of Cancer 2018: Genetic and Epigenetic Alterations in Pediatric Cancers
Grand Rapids, USA
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Known and novel roles of the MET oncogene in cancer: a coherent approach to targeted therapy    pp341 - 358
Paolo M. Comoglio, Livio Trusolino & Carla Boccaccio

The MET oncogene encodes a receptor tyrosine kinase with pleiotropic functions. In this Review, Comoglio et al. describe the known and novel MET-mediated biological responses in cancer and discuss how clinical trials testing anti-MET therapies should be designed with careful consideration of these oncogenic functions of MET.


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Nature Research Custom presents a webcast on: Multicolour Digital PCR for ctDNA detection in breast cancer

Date: 12 June 2018

Dr. Isaac Garcia-Murillas from ICR will address the technical challenges for clinical utility of liquid biopsy and ctDNA as a biomarker in breast cancer.

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A history of exploring cancer in context    pp359 - 376
Shelly Maman & Isaac P. Witz

In this Timeline article, Maman and Witz describe how much progress has been made in understanding how the tumour microenvironment influences tumour progression since its initial description, highlighting the controversies in the field and the potential of targeting components of the microenvironment for cancer therapy.


Structural underpinnings of oestrogen receptor mutations in endocrine therapy resistance    pp377 - 388
John A. Katzenellenbogen, Christopher G. Mayne, Benita S. Katzenellenbogen, Geoffrey L. Greene & Sarat Chandarlapaty

This Opinion article highlights how activating mutations in the gene encoding oestrogen receptor-α (ERα), a major driver in breast cancer, undermine structural features of wild-type ERα that maintain the ‘off-state’ in the absence of oestrogens, thus making ERα constitutively active and endocrine-therapy resistant.


Too many targets, not enough patients: rethinking neuroblastoma clinical trials    pp389 - 400
Jamie I. Fletcher, David S. Ziegler, Toby N. Trahair, Glenn M. Marshall, Michelle Haber et al.

This Perspective provides an update on targeted therapy development for neuroblastoma and proposes that clinical trial design needs to be rethought in order to provide rigorous, evidence-based assessment of these new therapies in this rare and often deadly paediatric tumour.


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