If you are still having problems viewing this message, please click here for additional help.

 
  journal cover  
Nature Volume 557 Issue 7706
 
This Week  
 
 
Editorial  
 
 
 
Science needs clarity on Europe’s data-protection law
Curbing global warming could save US$20 trillion
Customers put off electric cars … by electric-car sales staff
   
World View  
 
 
 
Beware: transparency rule is a Trojan Horse
Naomi Oreskes
Research Highlights  
 
 
 
This issue's Research Highlights
Selections from the scientific literature.
Seven Days  
 
 
 
Telescope pact, volcano explosion and migraine drug
 
 
Advertising.
 
 
News in Focus
 
News  
 
 
 
Experimental drugs poised for use in Ebola outbreak
Erika Check Hayden
Indonesian plan to clamp down on foreign scientists draws protest
Dyna Rochmyaningsih
Hawaii volcano eruption holds clues to predicting similar events elsewhere
Sara Reardon
Chinese satellite launch kicks off ambitious mission to Moon’s far side
Davide Castelvecchi
Europe’s open-access drive escalates as university stand-offs spread
Holly Else
Features  
 
 
 
How gut microbes are joining the fight against cancer
Giorgia Guglielmi
 
 
Multimedia  
 
 
Nature Podcast 24 May 2018
This week, the cost of climate change, cleverer cab journeys, and peering through matter with muons.
 
 
Comment
 
Comment  
 
 
 
The global south is rich in sustainability lessons that students deserve to hear
Harini Nagendra
Books and Arts  
 
 
 
Heredity beyond the gene
Nick Lane
Can robots make art?
Laura Spinney
The incomparable life of Nikola Tesla, inside Chernobyl, and the wilder shores of consciousness: Books in brief
Barbara Kiser
Correspondence  
 
 
 
Recruit young scientists and local talent to safeguard coral reefs
Gabby Ahmadia
Chilean Atacama site imperilled by lithium mining
Jorge S. Gutiérrez, Juan G. Navedo, Andrea Soriano-Redondo
Risks from technology-critical metals after extraction
Winfred Espejo, Cristóbal Galbán-Malagón, Gustavo Chiang Merimoyu
Publish translations of the best Chinese papers
Juan Tao, Chengzhi Ding, Yuh-Shan Ho
 
 
Technology
 
Technology Feature  
 
 
 
Single-cell approaches to immune profiling
Esther Landhuis
 
 
Careers
 
Features  
 
 
 
How to fit in when you join a lab abroad
Roberta Kwok
Q&A  
 
 
 
An ultralight way to manipulate brain signals
Virginia Gewin
 
 
Futures
 
DNA exchange

D. A. Xiaolin Spires
 
 
Research
 
NEW ONLINE  
 
 
 
Observation of anisotropic magneto-Peltier effect in nickel
A ‘magneto-Peltier effect’ produces cooling or heating in a material without junctions, by forcing a change in angle between the current and magnetization in a single ferromagnetic nickel slab.
An increase in the 12C + 12C fusion rate from resonances at astrophysical energies
The rate of carbon burning—12C + 12C fusion—in stars is boosted by resonant behaviour at astrophysical energies.
Activity-dependent neuroprotective protein recruits HP1 and CHD4 to control lineage-specifying genes
ADNP interacts with the chromatin remodeller CHD4 and the heterochromatin protein HP1 to form a complex termed ChAHP that represses gene expression independently of the histone H3K9me3 modification.
Self-organization of a human organizer by combined Wnt and Nodal signalling
Stimulation of Wnt and Nodal pathways in micropatterned human embryonic stem cell colonies induce these colonies to exhibit characteristic spatial expression patterns of the organizer and reproduce organizer function when grafted into a host embryo.
Cortical direction selectivity emerges at convergence of thalamic synapses
Direction selectivity emerges de novo in layer 4 neurons of primary visual cortex through the convergence of synaptic inputs from thalamic neurons that respond with distinct time courses to visual stimuli in distinct locations.
Structural basis of ubiquitin modification by the Legionella effector SdeA
Crystal structures of the Legionella effector SdeA in a ligand-free state and in complex with ubiquitin and NADH provide insight into SdeA-mediated phosphoribosyl-linked ubiquitination.
Mechanism of phosphoribosyl-ubiquitination mediated by a single Legionella effector
Crystal structures of the Legionella effectors SdeA and SdeD uncover the mechanism of a unique phosphoribosyl-ubiquitination reaction.
Insights into catalysis and function of phosphoribosyl-linked serine ubiquitination
Structural and functional investigations demonstrate how bacterial enzymes ubiquitinate host proteins.
Long-term effects of species loss on community properties across contrasting ecosystems
A long-term biodiversity manipulation experiment using plant communities on thirty Swedish lake islands reveals the importance of environmental context for determining the consequences of species loss at the ecosystem level.
Reciprocal signalling by Notch–Collagen V–CALCR retains muscle stem cells in their niche
Muscle stem cell quiescence in mice is maintained by a Notch–Collagen V–CALCR signalling pathway that is activated and sustained in a cell-autonomous fashion.
Reconstruction of antibody dynamics and infection histories to evaluate dengue risk
Analyses of antibody dynamics and subclinical infections show that across the population, variability in the infection strength of dengue viruses results in large-scale temporal changes in infection and disease risk that correlate poorly with age.
Late-surviving stem mammal links the lowermost Cretaceous of North America and Gondwana
An exceptionally preserved skull of Cifelliodon wahkarmoosuch sheds light on the evolution of the ancestral mammalian brain.
Body-size shifts in aquatic and terrestrial urban communities
The urban-heat-island effect drives community-level shifts towards smaller body sizes; however, habitat fragmentation caused by urbanization favours larger body sizes in species with positive size–dispersal links.
 
News & Views  
 
 
 
Pulsars seen through a new lens
Jason Hessels
 
Rethinking WNT signalling
Jessica A. Lehoczky, Clifford J. Tabin
 
Sizing up human brain evolution
Richard McElreath
 
Advertising.
Sabotage by the brain’s supporting cells helps fuel neurodegeneration
Lary C. Walker
Pancreatic cancer foiled by a switch of tumour subtype
Fieke Froeling, David Tuveson
Plasmon propagation pushed to the limit
Justin C. W. Song
The cost of a warming climate
Wolfram Schlenker, Maximilian Auffhammer
Articles  
 
 
 
Mutant phenotypes for thousands of bacterial genes of unknown function
A large-scale mutagenesis screen identifies mutant phenotypes for over 11,000 protein-coding genes in bacteria that had previously not been assigned a specific function.
Morgan N. Price, Kelly M. Wetmore, R. Jordan Waters et al.
ANKRD16 prevents neuron loss caused by an editing-defective tRNA synthetase
ANKRD16 attenuates neurodegeneration induced by a mutation in the editing domain of alanyl tRNA synthetase by directly accepting mis-activated serine from the synthetase before transfer to the tRNA, establishing a new mechanism by which editing defects are prevented.
My-Nuong Vo, Markus Terrey, Jeong Woong Lee et al.
SWI2/SNF2 ATPase CHR2 remodels pri-miRNAs via Serrate to impede miRNA production
The chromatin remodelling protein CHR2 interacts with Serrate in Arabidopsis to regulate microRNA biogenesis.
Zhiye Wang, Zeyang Ma, Claudia Castillo-González et al.
Letters  
 
 
 
Pulsar emission amplified and resolved by plasma lensing in an eclipsing binary
Radiation from the ‘black widow’ pulsar B1957+20 is amplified when a companion brown dwarf passes in front of the source, suggesting that plasma flowing from the companion acts as a lens.
Robert Main, I-Sheng Yang, Victor Chan et al.
An absolute sodium abundance for a cloud-free ‘hot Saturn’ exoplanet
The optical transmission spectrum for the ‘hot Saturn’ exoplanet WASP-96b reveals a clear atmosphere, an atmospheric sodium abundance and hence its metallicity, which is consistent with the metallicity trend observed in Solar System planets and exoplanets.
N. Nikolov, D. K. Sing, J. J. Fortney et al.
Fundamental limits to graphene plasmonics
The fundamental limits to plasmon damping in graphene are determined using nanoscale infrared imaging at cryogenic temperatures, and plasmon polaritons are observed to propagate over 10 micrometres in high-mobility encapsulated graphene.
G. X. Ni, A. S. McLeod, Z. Sun et al.
Addressing the minimum fleet problem in on-demand urban mobility
An optimal computationally efficient solution to the problem of finding the minimum taxi fleet size using a vehicle-sharing network is presented.
M. M. Vazifeh, P. Santi, G. Resta et al.
Self-reporting and self-regulating liquid crystals
Liquid crystals are used to self-report and self-regulate either continuous or transient release of droplets or microparticles trapped within them in response to thermal, chemical, mechanical or biological stimuli.
Young-Ki Kim, Xiaoguang Wang, Pranati Mondkar et al.
Rapid emergence of subaerial landmasses and onset of a modern hydrologic cycle 2.5 billion years ago
The use of triple-oxygen-isotope data from continental shales spanning the past 3.7 billion years suggests that continental crust with near-modern average elevation and extent emerged about 2.5 billion years ago.
I. N. Bindeman, D. O. Zakharov, J. Palandri et al.
Large potential reduction in economic damages under UN mitigation targets
If the world can meet the target of limiting global warming to 1.5 °C, economic damage will probably be greatly reduced, especially in poorer countries.
Marshall Burke, W. Matthew Davis, Noah S. Diffenbaugh
Inference of ecological and social drivers of human brain-size evolution
Using estimates of metabolic costs of the brain and body, mathematical predictions suggest that the evolution of adult Homo sapiens-sized brains and bodies is driven by ecological rather than social challenges and is perhaps strongly promoted by culture.
Mauricio González-Forero, Andy Gardner
Cellular milieu imparts distinct pathological α-synuclein strains in α-synucleinopathies
Distinct strains of misfolded α-synuclein proteins, which aggregate in neurons in Lewy body diseases or in oligodendrocytes in multiple system atrophy, are formed as a consequence of differences between intracellular environments.
Chao Peng, Ronald J. Gathagan, Dustin J. Covell et al.
RSPO2 inhibition of RNF43 and ZNRF3 governs limb development independently of LGR4/5/6
Independently of the LGR4/5/6 receptors, RSPO2 acts as a direct antagonistic ligand to RNF43 and ZNRF3 during embryogenesis, and specifies the position and number of limbs that an embryo should form.
Emmanuelle Szenker-Ravi, Umut Altunoglu, Marc Leushacke et al.
Mxra8 is a receptor for multiple arthritogenic alphaviruses
The cell adhesion molecule Mxra8 is identified as a receptor for multiple arthritogenic alphaviruses such as chikungunya virus, and anti-Mxra8 monoclonal antibodies are shown to reduce rates of chikungunya virus infection in mice and a range of human cells.
Rong Zhang, Arthur S. Kim, Julie M. Fox et al.
Bystander CD8+ T cells are abundant and phenotypically distinct in human tumour infiltrates
Human lung and colorectal tumours contain a population of tumour-infiltrating lymphocytes that are specific for tumour-unrelated antigens and, unlike tumour-antigen-specific tumour-infiltrating lymphocytes, do not express CD39.
Yannick Simoni, Etienne Becht, Michael Fehlings et al.
Microbial signals drive pre-leukaemic myeloproliferation in a Tet2-deficient host
Microbial signals are crucial to the development of pre-leukaemic myeloproliferation, which can be induced by disrupting the intestinal barrier or by introducing systemic bacterial stimuli in Tet2-deficient mice.
Marlies Meisel, Reinhard Hinterleitner, Alain Pacis et al.
KLHL22 activates amino-acid-dependent mTORC1 signalling to promote tumorigenesis and ageing
In response to amino acid stimulation, the ubiquitin E3 ligase CUL3–KLHL22 promotes the activation of mTORC1, which may drive tumour growth in breast cancer.
Jie Chen, Yuhui Ou, Yanyan Yang et al.
Structural basis for gating pore current in periodic paralysis
Crystal structures and molecular dynamics simulations of voltage-gated sodium channels containing mutations that cause hypokalaemic and normokalaemic periodic paralysis indicate the pathogenic mechanisms of these conditions and suggest a target for the design of potential therapeutic and symptomatic drugs.
Daohua Jiang, Tamer M. Gamal El-Din, Christopher Ing et al.
 
 
Spotlight
 
Spotlight  
 
 
 
Spotlight on Hong Kong
Jack Leeming
 
 
KACST Impact

KACST Impact is a new online publication highlighting the latest cutting edge scientific research conducted at King Abdulaziz City for Science and Technology (KACST) that features various stories ranging from exciting new scientific finds to the commercialization of innovative discoveries. 

Learn more »
 
 
 
 
 

naturejobs.com

naturejobs.com Science jobs of the week

 
 
 

Ph. D. position

 
 

Darmstadt University of Technology (TU Darmstadt) 

 
 
 
 
 

Postodoctoral Fellow

 
 

University of California (UCSF) 

 
 
 
 
 

Cancer Research

 
 

University of Ottawa / Université d’Ottawa  

 
 
 
 
 

Principal Scientist

 
 

Talisman Therapeutics Ltd 

 
 
 
 

No matter what your career stage, student, postdoc or senior scientist, you will find articles on naturejobs.com to help guide you in your science career. Keep up-to-date with the latest sector trends, vote in our reader poll and sign-up to receive the monthly Naturejobs newsletter.

 
 
 
 
 
 
 

natureevents.com - The premier science events website

natureevents directory featured events

 
 
 
 

International Conference on Surgery and Medicine

 
 

16 July Bangkok, Thailand

 
 
 
 

Natureevents Directory is the premier resource for scientists looking for the latest scientific conferences, courses, meetings and symposia. Featured across Nature Publishing Group journals and centrally at natureevents.com it is an essential reference guide to scientific events worldwide.

 
 
 
 
 
Your email address is in the Nature mailing list.

You have been sent this Table of Contents Alert because you have opted in to receive it. You can change or discontinue your e-mail alerts at any time, by modifying your preferences on your nature.com account at: www.nature.com/nams/svc/myaccount (You will need to log in to be recognised as a nature.com registrant).
 
 
 
For further technical assistance, please contact our registration department at registration@nature.com

For print subscription enquiries, please contact our subscription department at subscriptions@nature.com

For other enquiries, please contact feedback@nature.com

Nature Research | One New York Plaza, Suite 4500 | New York | NY 10004-1562 | USA

Nature Research's offices:

Principal offices: London - New York - Tokyo

Worldwide offices: Basingstoke - Beijing - Boston - Buenos Aires - Delhi - Heidelberg - Hong Kong - Madrid - Melbourne - Munich - Paris - San Francisco - Seoul - Shanghai - Washington DC - Sydney

Macmillan Publishers Limited is a company incorporated in England and Wales under company number 785998 and whose registered office is located at The Campus, 4 Crinan Street, London, N1 9XW.

© 2018 Macmillan Publishers Limited. All Rights Reserved.