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Nature Reviews Immunology

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TABLE OF CONTENTS

June 2018 Volume 18, Issue 6

Research Highlights
Reviews
Perspectives
 
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Research Highlights

 

Reigning in RIG-I    p357
Lucy Bird
doi:10.1038/s41577-018-0018-2

Specificity for HCMV strains    pp358 - 359
Kirsty Minton
doi:10.1038/s41577-018-0010-x

Strain-specific recognition of different UL40 peptides determines the proliferation and activation of NKG2C+ NK cells during HCMV infection.

 

Microglial memory    pp358 - 359
Lucy Bird
doi:10.1038/s41577-018-0015-5

Microglial cells show innate immune memory of peripheral inflammatory stimuli that influences neurological disease pathology.

 

γδ T cells turn up the heat    p359
Grant Otto
doi:10.1038/s41577-018-0017-3

γδ T cells have a crucial role in immune homeostasis and thermogenesis in adipose tissues through their production of IL-17A and TNF.

 

Viral tropism for tuft cells    pp360 - 361
Kirsty Minton
doi:10.1038/s41577-018-0011-9

Norovirus infection of tuft cells in the intestinal epithelium can be promoted by type 2 cytokines.

 

Itaconate charges down inflammation    pp360 - 361
Yvonne Bordon
doi:10.1038/s41577-018-0016-4

The metabolite itaconate induces electrophilic stress that induces an antioxidant response and regulates secondary TLR transcriptional responses and IL-17-driven pathology.

 

The IFN road not taken    p361
Yvonne Bordon
doi:10.1038/s41577-018-0012-8

SAMHD1 promotes the degradation of nascent DNA strands to protect against aberrant activation of the pro-inflammatory cGAS–STING pathway by self DNA.

 

Nature Reviews Immunology
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Reviews

 

The full spectrum of human naive T cells    pp363 - 373
Theo van den Broek, José A. M. Borghans & Femke van Wijk
doi:10.1038/s41577-018-0001-y

Evidence is increasing that naive T cells are heterogeneous in phenotype, function, dynamics and differentiation status. Here, van den Broek et al. provide a revised view of the naive T cell compartment and then discuss the implications for ageing, neonatal immunity and T cell reconstitution following haematopoietic stem cell transplantation.

 

C-type lectins in immunity and homeostasis    pp374 - 389
Gordon D. Brown, Janet A. Willment & Lauren Whitehead
doi:10.1038/s41577-018-0004-8

Recently discovered roles for C-type lectins in development, homeostasis, cell death, cancer and autoimmune and inflammatory diseases extend the functions of this superfamily beyond their well-recognized involvement in antimicrobial responses.

 

Nonhuman primate models of human viral infections    pp390 - 404
Jacob D. Estes, Scott W. Wong & Jason M. Brenchley
doi:10.1038/s41577-018-0005-7

Nonhuman primates (NHPs) are increasingly used as models of human viral infections. Here, Estes and colleagues introduce different NHP models, summarize the similarities and differences between human and NHP immune systems and discuss important examples of human viruses that can be modelled in NHPs.

 

Perspectives

 

To respond or not to respond — a personal perspective of intestinal tolerance    pp405 - 415
Allan McI. Mowat
doi:10.1038/s41577-018-0002-x

In this Timeline, Allan Mowat reflects on some of the key discoveries that have shaped our understanding of how immune tolerance towards environmental antigens, such as commensal bacteria and food proteins, develops and is maintained in the intestine.

 

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