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TABLE OF CONTENTS

June 2018 Volume 36, Issue 6

Editorials
News
News Feature
Bioentrepreneur
Features
News and Views
Research
Letter
Careers and Recruitment
 
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Editorials

 

DIYbio gets a poxy rap   p477
doi:10.1038/nbt.4170
Contrary to alarmist headlines, the DIYbio movement is an unlikely biosecurity threat.
 

Human embryo research policy update   p477
doi:10.1038/nbt.4171
Ethics standards for studies that report human embryo and stem cell research.
 

News

 

Mammoth, Arbor and Beam launch new wave of CRISPR startups   pp479 - 480
Cormac Sheridan
doi:10.1038/nbt0618-479
 

Pear approval signals FDA readiness for digital treatments   pp481 - 482
Emily Waltz
doi:10.1038/nbt0618-481
 

Hong Kong stock exchange opens to biotechs   p482
Shannon Ellis
doi:10.1038/nbt0618-482
 

Everything but amyloid: new thinking prompts FDA revamp   pp483 - 484
Eva von Schaper
doi:10.1038/nbt0618-483
 

Next-generation sequencing tests to become routine   p484
Mark Ratner
doi:10.1038/nbt0618-484
 

As CRISPR-Cas adoption soars, summit calls for genome editing oversight   p485
Eric Smalley
doi:10.1038/nbt0618-485
 

Around the world in a month   p486
doi:10.1038/nbt0618-486
 

Data Page

1Q18—the risk-capital roll continues   p487
Laura DeFrancesco
doi:10.1038/nbt.4160
 

News Feature

 

Beating the organ clock   pp488 - 492
Melanie Senior
doi:10.1038/nbt.4157
Donor organ monitoring and ex vivo perfusion technology are transforming transplantation and offering new therapeutic opportunities. Melanie Senior reports.
 

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Bioentrepreneur

 
Data Page

Research biotech patenting 2017   pp493 - 494
Brady Huggett and Kathryn Paisner
doi:10.1038/nbt.4156
 

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Features

 
Patents

The ethics of access to patented biotech research tools from universities and other research institutions   pp495 - 499
Knut J Egelie, Sabina P Strand, Berit Johansen and Bjørn K Myskja
doi:10.1038/nbt.4165
As universities and public research organizations increasingly partner with industry to fulfill their 'third mission' of innovation activities for economic and societal benefit, they have ethical obligations to ensure access to patented research tools, especially CRISPR-Cas9 technology.
 

Recent patents in metabolomics and metabolic engineering   p500
doi:10.1038/nbt.4168
 

News and Views

 

Profiling DNA-transcription factor interactions   pp501 - 502
Cheen Euong Ang and Marius Wernig
doi:10.1038/nbt.4161
Global transcription factor activity is measured by screening cell extracts with an oligonucleotide library.
 

Research Highlights   p502
doi:10.1038/nbt.4159
 

SCRaMbLE does the yeast genome shuffle   p503
Susan Jones
doi:10.1038/nbt.4164
 

Getting warmer with liver transplants   p504
Irene Jarchum
doi:10.1038/nbt.4158
 

Biotechnology
JOBS of the week
Postdoctor position in diatom / microalgae biotechnology
Norwegian University of Science and Technology
Associate Professor
Monash University
Research Fellow (Bioinformatics)
Agency for Science, Technology and Research (A*STAR)
Faculty Positions in School of Biotechnology, Jiangnan University
Jiangnan University
Assistant Professor in Biology / Biotechnology at the Hong Kong Polytechnic University (Ref. 18041901)
The Hong Kong Polytechnic University
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Biotechnology
EVENT
Proteins and Peptides: Structure, Function and Biotechnology
23.07.18
Genève, Switzerland
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Research

 
Brief Communications

Genome-scale engineering of Saccharomyces cerevisiae with single-nucleotide precision   pp505 - 508
Zehua Bao, Mohammad HamediRad, Pu Xue, Han Xiao, Ipek Tasan et al.
doi:10.1038/nbt.4132
Efficient genome-scale precision editing in yeast is enabled using CRISPR-Cas9 and homology-directed-repair.
 

Reversal of siRNA-mediated gene silencing in vivo    pp509 - 511
Ivan Zlatev, Adam Castoreno, Christopher R Brown, June Qin, Scott Waldron et al.
doi:10.1038/nbt.4136
Gene silencing by siRNAs in vivo is reversed using sequence-specific high-affinity oligonucleotides.
 

Articles

Multiplexed precision genome editing with trackable genomic barcodes in yeast   pp512 - 520
Kevin R Roy, Justin D Smith, Sibylle C Vonesch, Gen Lin, Chelsea Szu Tu et al.
doi:10.1038/nbt.4137
A method to introduce defined mutations into the yeast genome enables saturation mutagenesis of a gene and genome-scale introduction of genetic variants.
 

A protein activity assay to measure global transcription factor activity reveals determinants of chromatin accessibility   pp521 - 529
Bei Wei, Arttu Jolma, Biswajyoti Sahu, Lukas M Orre, Fan Zhong et al.
doi:10.1038/nbt.4138
A method to analyze global transcription factor activity in cells reveals that a small number of factors determines the landscape of accessible chromatin.
 

Letter

Photosynthetic artificial organelles sustain and control ATP-dependent reactions in a protocellular system   pp530 - 535
Keel Yong Lee, Sung-Jin Park, Keon Ah Lee, Se-Hwan Kim, Heeyeon Kim et al.
doi:10.1038/nbt.4140
Vesicles that convert light energy to ATP are used to power a protocellular system.
 

Letter

 

Adenine base editing in mouse embryos and an adult mouse model of Duchenne muscular dystrophy   pp536 - 539
Seuk-Min Ryu, Taeyoung Koo, Kyoungmi Kim, Kayeong Lim, Gayoung Baek et al.
doi:10.1038/nbt.4148
Adenine base editing is used to treat a mouse model of Duchenne muscular dystrophy and to create defined mutations in mouse embryos.
 

Research

 
Letters

High-throughput creation and functional profiling of DNA sequence variant libraries using CRISPR-Cas9 in yeast   pp540 - 546
Xiaoge Guo, Alejandro Chavez, Angela Tung, Yingleong Chan, Christian Kaas et al.
doi:10.1038/nbt.4147
An optimized method to introduce precise modifications into the yeast genome enables high-throughput characterization of the phenotypic effect of mutations.
 

Secure genome-wide association analysis using multiparty computation   pp547 - 551
Hyunghoon Cho, David J Wu and Bonnie Berger
doi:10.1038/nbt.4108
A computational protocol built upon modern cryptographic techniques enables secure analysis of large-scale genetic data.
 

Careers and Recruitment

 

Optimizing the utility of the individual development plan for trainees in the biosciences   pp552 - 553
Jessica W Tsai, Nathan L Vanderford and Fanuel Muindi
doi:10.1038/nbt.4155
Obtaining more data on how institutions, faculty and trainees utilize the individual development plan can only increase its usefulness for exploring both academic and non-academic careers.
 

People

People   p554
doi:10.1038/nbt.4169
 

 
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