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Better Understand Cellular Interactions To Improve Cancer Vaccine Efficacy

Learn how researchers were able to characterize the blood-borne BDCA1+CD14+ myeloid cell population within blood and tissue of healthy individuals versus cancer patients, and their negative effect on T-cell proliferation, in order to improve tumor vaccine efficacy in this case study. 
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TABLE OF CONTENTS

July 2018 Volume 19, Issue 7

Research Highlights
News & Views
Editorial
Review Articles
Articles
Resources
 
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Viral Infection and Immune Response

This conference aims to stimulate the interaction between the fields of virology and immunology in order to advance our understanding of viral epidemiology and pathogenesis, as well as the innate and adaptive immune responses elicited by the host.
October 12-14, 2018 | Shanghai, China

 
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Nature Spotlight on Hong Kong: building science innovation 

Hong Kong is maximising major scientific innovation and commercial benefits through its proximity to the research and development hubs in mainland China. Yet barriers to collaboration remain.

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Research Highlights

 

Both local and global    p647
Ioana Visan
doi:10.1038/s41590-018-0146-7

Fiber against flu    p647
Ioana Visan
doi:10.1038/s41590-018-0147-6

Targeting Ebola    p647
Laurie A. Dempsey
doi:10.1038/s41590-018-0148-5

4PD1hi T cells    p647
Laurie A. Dempsey
doi:10.1038/s41590-018-0149-4

TILs on standby    p647
Zoltan Fehervari
doi:10.1038/s41590-018-0150-y

Dysbiosis shapes vaccine responses    p647
Zoltan Fehervari
doi:10.1038/s41590-018-0151-x

Immunology
JOBS of the week
Faculty position
Sabanci University
Immunology / Molecular Biology Postdoctoral Position
National Heart, Lung and Blood Institute
Associate / Full Professor - Immunobioengineering
University of Toronto
Postdoctoral Fellow in Cardiovascular Immunology / Hematology
Massachuesetts General Hospital / Harvard Medical School
Cancer Immunology Fellowship
University College Cork
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Immunology
EVENT
Immunogenicity and Bioassay Summit 2018
22.10.18
Alexandria, USA
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News & Views

 

Get the IL-17F outta here!    pp648 - 650
Aisling O’Hara Hall, Jennifer E. Towne & Scott E. Plevy
doi:10.1038/s41590-018-0141-z

Checkpoint inhibition: NK cells enter the scene    pp650 - 652
Ana Stojanovic & Adelheid Cerwenka
doi:10.1038/s41590-018-0142-y

Plasmacytoid dendritic cells: origin matters    pp652 - 654
Markus G. Manz
doi:10.1038/s41590-018-0143-x

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Editorial

 

Living with the enemy    p658
doi:10.1038/s41590-018-0153-8

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One of the most important ingredients in breast milk you've never heard of

Nutrition matters, and early diet has life-long effects. So how are indigestible molecules in breast milk helping ensure the healthiest start for both breast-fed and formula-fed babies?

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Produced for Abbott by Nature Research Custom Media 

Content intended for healthcare professionals.
 

Review Articles

 

Thymic tolerance as a key brake on autoimmunity    pp659 - 664
Mickie Cheng & Mark S. Anderson
doi:10.1038/s41590-018-0128-9

The thymus has a critical role in the establishment of appropriately educated and self-tolerant T cells. In their Focus Review, Cheng and Anderson discuss the most recent insights into how the thymus establishes self-tolerance.

 

Regulatory T cells in autoimmune disease    pp665 - 673
Margarita Dominguez-Villar & David A. Hafler
doi:10.1038/s41590-018-0120-4

Treg cells have a critical role in maintaining peripheral tolerance. In this Focus Review, Dominguez-Villar and Hafler describe how the instability and plasticity of Treg cells can contribute to the breakdown of tolerance and lead to autoimmune disease.

 

Approaches and advances in the genetic causes of autoimmune disease and their implications    pp674 - 684

doi:10.1038/s41590-018-0129-8

Autoimmune disease has been the subject of intense genetic study. In this Focus Review, Todd and colleagues describe recent advances and approaches in the genetic analysis of autoimmune disease.

 

Common ground: shared risk factors for type 1 diabetes and celiac disease    pp685 - 695
Elena F. Verdu & Jayne S. Danska
doi:10.1038/s41590-018-0130-2

The rates of autoimmune disease are rising more rapidly than can be explained by changes in genetics. In this Focus Review, Verdu and Danska describe the dietary and microbial influences on type 1 diabetes and draw comparisons with celiac disease.

 

Reassessing B cell contributions in multiple sclerosis    pp696 - 707
Rui Li, Kristina R. Patterson & Amit Bar-Or
doi:10.1038/s41590-018-0135-x

In this Focus Review, Bar-Or and colleagues discuss the latest evidence that B cells play an important antibody-independent role in multiple sclerosis and the prospects this holds for therapeutic intervention.

 

Articles

 

Distinct progenitor lineages contribute to the heterogeneity of plasmacytoid dendritic cells    pp711 - 722
Patrick Fernandes Rodrigues, Llucia Alberti-Servera, Anna Eremin, Gary E. Grajales-Reyes, Robert Ivanek et al.
doi:10.1038/s41590-018-0136-9

Tussiwand and colleagues show that pDCs develop predominantly from IL-7R+ lymphoid progenitor cells and that mature pDCs are transcriptionally and functionally heterogenous, on the basis of their lymphoid or myeloid lineage.

 

Blockade of the checkpoint receptor TIGIT prevents NK cell exhaustion and elicits potent anti-tumor immunity    pp723 - 732
Qing Zhang, Jiacheng Bi, Xiaodong Zheng, Yongyan Chen, Hua Wang et al.
doi:10.1038/s41590-018-0132-0

TIGIT is a co-inhibitory receptor associated with T cell exhaustion. Tian and colleagues demonstrate that TIGIT is the predominant inhibitory receptor on NK cells in both humans and mice and that its blockade enhances NK cell–dependent rejection of tumors in experimental models.

 

Lck promotes Zap70-dependent LAT phosphorylation by bridging Zap70 to LAT    pp733 - 741
Wan-Lin Lo, Neel H. Shah, Nagib Ahsan, Veronika Horkova, Ondrej Stepanek et al.
doi:10.1038/s41590-018-0131-1

TCR signaling initiates a signaling cascade involving the kinases Lck and Zap70 and the adaptor LAT. Weiss and colleagues discover a proline-rich motif in LAT, which facilitates interactions among Lck, LAT and Zap70 for efficient TCR signaling.

 

Clonal analysis of Salmonella-specific effector T cells reveals serovar-specific and cross-reactive T cell responses    pp742 - 754
Giorgio Napolitani, Prathiba Kurupati, Karen Wei Weng Teng, Malick M. Gibani, Margarida Rei et al.
doi:10.1038/s41590-018-0133-z

Typhoidal Salmonella is a major pathogen, but there is still a lack of knowledge about suitable vaccine antigens. Cerundolo and colleagues deep-phenotype bacteria-specific CD4+ T cells of Salmonella-infected volunteers to define cross-reactive and serovar-specific responses.

 

Suppression of IL-17F, but not of IL-17A, provides protection against colitis by inducing Treg cells through modification of the intestinal microbiota    pp755 - 765
Ce Tang, Shigeru Kakuta, Kenji Shimizu, Motohiko Kadoki, Tomonori Kamiya et al.
doi:10.1038/s41590-018-0134-y

The cytokines IL-17A and IL-17F bind via same receptor. Iwakura and colleagues demonstrate different functions for IL-17A and IL-17F in the gut, with the latter altering the production of antimicrobial peptides with consequent effects on the microbiota, the induction of Treg cells and immune-system homeostasis.

 

The E3 ligases Itch and WWP2 cooperate to limit TH2 differentiation by enhancing signaling through the TCR    pp766 - 775
Daisuke Aki, Hui Li, Wen Zhang, Mingke Zheng, Chris Elly et al.
doi:10.1038/s41590-018-0137-8

Liu and colleagues show that the ubiquitin E3 ligases Itch and WWP2 act together in regulating the strength of the TCR signal and differentiation toward the TH2 lineage.

 

Resources

 

Integration of multi-omics data and deep phenotyping enables prediction of cytokine responses    pp776 - 786
Olivier B. Bakker, Raul Aguirre-Gamboa, Serena Sanna, Marije Oosting, Sanne P. Smeekens et al.
doi:10.1038/s41590-018-0121-3

The immune response to pathogens varies substantially among humans. Netea and colleagues show that integration of multi-omics data and deep phenotyping enables prediction of cytokine production in responses to pathogens.

 

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