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Cell Death & Disease

Volume 9 (June 2018)

In this issue
Review Article



The Hsp70 inhibitor 2-phenylethynesulfonamide inhibits replication and carcinogenicity of Epstein–Barr virus by inhibiting the molecular chaperone function of Hsp70

Huan Wang, Lang Bu, Chao Wang, Yaqian Zhang, Heng Zhou et al.

Cell Death & Disease 2018 9: 10.1038/s41419-018-0779-3

Abstract | Full Text

GABA promotes survival and axonal regeneration in identifiable descending neurons after spinal cord injury in larval lampreys

Daniel Romaus-Sanjurjo, Rocío Ledo-García, Blanca Fernández-López, Kendra Hanslik, Jennifer R. Morgan et al.

Cell Death & Disease 2018 9: 10.1038/s41419-018-0704-9

Abstract | Full Text

Parkin regulates NF-κB by mediating site-specific ubiquitination of RIPK1

Yu Wang, Bing Shan, Yaosi Liang, Huiting Wei & Junying Yuan

Cell Death & Disease 2018 9: 10.1038/s41419-018-0770-z

Abstract | Full Text

Epidermal-specific deletion of TC-PTP promotes UVB-induced epidermal cell survival through the regulation of Flk-1/JNK signaling

Minwoo Baek, Mihwa Kim, Jae Sung Lim, Liza D. Morales, Joselin Hernandez et al.

Cell Death & Disease 2018 9: 10.1038/s41419-018-0781-9

Abstract | Full Text

Glutamate as a potential “survival factor” in an in vitro model of neuronal hypoxia/reoxygenation injury: leading role of the Na+/Ca2+ exchanger

Silvia Piccirillo, Pasqualina Castaldo, Maria Loredana Macrì, Salvatore Amoroso & Simona Magi

Cell Death & Disease 2018 9: 10.1038/s41419-018-0784-6

Abstract | Full Text

Inhibition of excessive autophagy and mitophagy mediates neuroprotective effects of URB597 against chronic cerebral hypoperfusion

Shao-Hua Su, Yi-Fang Wu, Da-Peng Wang & Jian Hai

Cell Death & Disease 2018 9: 10.1038/s41419-018-0755-y

Abstract | Full Text

High-throughput analysis of the RNA-induced silencing complex in myotonic dystrophy type 1 patients identifies the dysregulation of miR-29c and its target ASB2

Marisa Cappella, Alessandra Perfetti, Beatrice Cardinali, Jose Manuel Garcia-Manteiga, Matteo Carrara et al.

Cell Death & Disease 2018 9: 10.1038/s41419-018-0769-5

Abstract | Full Text

Proton irradiation orchestrates macrophage reprogramming through NFκB signaling

Géraldine Genard, Anne-Catherine Wera, Camille Huart, Benjamin Le Calve, Sébastien Penninckx et al.

Cell Death & Disease 2018 9: 10.1038/s41419-018-0757-9

Abstract | Full Text

Nogo-A inactivation improves visual plasticity and recovery after retinal injury

Julius Baya Mdzomba, Noémie Jordi, Léa Rodriguez, Sandrine Joly, Frédéric Bretzner et al.

Cell Death & Disease 2018 9: 10.1038/s41419-018-0780-x

Abstract | Full Text

NLRP3 inflammasome is expressed and regulated in human islets

Fanny Lebreton, Ekaterine Berishvili, Géraldine Parnaud, Caroline Rouget, Domenico Bosco et al.

Cell Death & Disease 2018 9: 10.1038/s41419-018-0764-x

Abstract | Full Text

NCX1 and NCX3 as potential factors contributing to neurodegeneration and neuroinflammation in the A53T transgenic mouse model of Parkinson’s Disease

Rossana Sirabella, Maria Josè Sisalli, Giulia Costa, Katia Omura, Gaetano Ianniello et al.

Cell Death & Disease 2018 9: 10.1038/s41419-018-0775-7

Abstract | Full Text

Cardiac-derived CTRP9 protects against myocardial ischemia/reperfusion injury via calreticulin-dependent inhibition of apoptosis

Dajun Zhao, Pan Feng, Yang Sun, Zhigang Qin, Zhengbin Zhang et al.

Cell Death & Disease 2018 9: 10.1038/s41419-018-0726-3

Abstract | Full Text

SERPINB2 is a novel indicator of stem cell toxicity

Na-Hee Lee, Ara Cho, Se-Ra Park, Jin Woo Lee, Park Sung Taek et al.

Cell Death & Disease 2018 9: 10.1038/s41419-018-0748-x

Abstract | Full Text

Differential antiviral immunity to Japanese encephalitis virus in developing cortical organoids

Boya Zhang, Yangzhige He, Yanpeng Xu, Fan Mo, Tingwei Mi et al.

Cell Death & Disease 2018 9: 10.1038/s41419-018-0763-y

Abstract | Full Text

Anticancer chemotherapy and radiotherapy trigger both non-cell-autonomous and cell-autonomous death

Isabelle Martins, Syed Qasim Raza, Laurent Voisin, Haithem Dakhli, Awatef Allouch et al.

Cell Death & Disease 2018 9: 10.1038/s41419-018-0747-y

Abstract | Full Text

IL-4 enhances survival of in vitro-differentiated mouse basophils through transcription-independent signaling downstream of PI3K

Ramona Reinhart & Thomas Kaufmann

Cell Death & Disease 2018 9: 10.1038/s41419-018-0754-z

Abstract | Full Text

CXCR1/Akt signaling activation induced by mesenchymal stem cell-derived IL-8 promotes osteosarcoma cell anoikis resistance and pulmonary metastasis

Lin Du, Xiu-guo Han, Bing Tu, Min-qi Wang, Han Qiao et al.

Cell Death & Disease 2018 9: 10.1038/s41419-018-0745-0

Abstract | Full Text

MicroRNA-214 promotes hepatic stellate cell activation and liver fibrosis by suppressing Sufu expression

Liping Ma, Xiaoxue Yang, Rong Wei, Tinghong Ye, Jian-Kang Zhou et al.

Cell Death & Disease 2018 9: 10.1038/s41419-018-0752-1

Abstract | Full Text

Long intergenic non-coding RNA 00324 promotes gastric cancer cell proliferation via binding with HuR and stabilizing FAM83B expression

Zigui Zou, Tianshi Ma, Xuezhi He, Jinxing Zhou, Hongwei Ma et al.

Cell Death & Disease 2018 9: 10.1038/s41419-018-0758-8

Abstract | Full Text

Natural cyclopeptide RA-V inhibits the NF-κB signaling pathway by targeting TAK1

Zhe Wang, Simeng Zhao, Lihua Song, Yuzhi Pu, Qiang Wang et al.

Cell Death & Disease 2018 9: 10.1038/s41419-018-0743-2

Abstract | Full Text

MicroRNA-378 is involved in hedgehog-driven epithelial-to-mesenchymal transition in hepatocytes of regenerating liver

Jieun Kim, Jeongeun Hyun, Sihyung Wang, Chanbin Lee & Youngmi Jung

Cell Death & Disease 2018 9: 10.1038/s41419-018-0762-z

Abstract | Full Text

LncRNA SNHG7 sponges miR-216b to promote proliferation and liver metastasis of colorectal cancer through upregulating GALNT1

Yujia Shan, Jia Ma, Yue Pan, Jialei Hu, Bing Liu et al.

Cell Death & Disease 2018 9: 10.1038/s41419-018-0759-7

Abstract | Full Text

miR-129 controls axonal regeneration via regulating insulin-like growth factor-1 in peripheral nerve injury

Hui Zhu, Chengbin Xue, Min Yao, Hongkui Wang, Ping Zhang et al.

Cell Death & Disease 2018 9: 10.1038/s41419-018-0760-1

Abstract | Full Text

Long non-coding RNA HOTAIR promotes osteoarthritis progression via miR-17-5p/FUT2/β-catenin axis

Jialei Hu, Zi Wang, Yujia Shan, Yue Pan, Jia Ma et al.

Cell Death & Disease 2018 9: 10.1038/s41419-018-0746-z

Abstract | Full Text

Inhibition of ANO1/TMEM16A induces apoptosis in human prostate carcinoma cells by activating TNF-α signaling

Yan Song, Jian Gao, Lizhao Guan, Xiaoling Chen, Jianjun Gao et al.

Cell Death & Disease 2018 9: 10.1038/s41419-018-0735-2

Abstract | Full Text

Glaucocalyxin A exerts anticancer effect on osteosarcoma by inhibiting GLI1 nuclear translocation via regulating PI3K/Akt pathway

Jianwei Zhu, Yang Sun, Ying Lu, Xiubo Jiang, Bo Ma et al.

Cell Death & Disease 2018 9: 10.1038/s41419-018-0684-9

Abstract | Full Text

Mitochondrial Lon sequesters and stabilizes p53 in the matrix to restrain apoptosis under oxidative stress via its chaperone activity

Ya-Ju Sung, Ting-Yu Kao, Cheng-Liang Kuo, Chi-Chen Fan, An Ning Cheng et al.

Cell Death & Disease 2018 9: 10.1038/s41419-018-0730-7

Abstract | Full Text

Proscillaridin A induces apoptosis and suppresses non-small-cell lung cancer tumor growth via calcium-induced DR4 upregulation

Run-Ze Li, Xing-Xing Fan, Fu-Gang Duan, Ze-Bo Jiang, Hu-Dan Pan et al.

Cell Death & Disease 2018 9: 10.1038/s41419-018-0733-4

Abstract | Full Text

Downregulation of HS6ST2 by miR-23b-3p enhances matrix degradation through p38 MAPK pathway in osteoarthritis

Yuanxu Guo, Zixin Min, Congshan Jiang, Wei Wang, Jidong Yan et al.

Cell Death & Disease 2018 9: 10.1038/s41419-018-0729-0

Abstract | Full Text

Magnolin promotes autophagy and cell cycle arrest via blocking LIF/Stat3/Mcl-1 axis in human colorectal cancers

Haiyang Yu, Shuangshuang Yin, Shiyue Zhou, Yingying Shao, Jiachen Sun et al.

Cell Death & Disease 2018 9: 10.1038/s41419-018-0660-4

Abstract | Full Text

Jnk2 deficiency increases the rate of glaucomatous neurodegeneration in ocular hypertensive DBA/2J mice

Jeffrey M. Harder, Pete A. Williams, Ileana Soto, Nicole E. Foxworth, Kimberly A. Fernandes et al.

Cell Death & Disease 2018 9: 10.1038/s41419-018-0705-8

Abstract | Full Text

Linc00462 promotes pancreatic cancer invasiveness through the miR-665/TGFBR1-TGFBR2/SMAD2/3 pathway

Bin Zhou, Weidong Guo, Chuandong Sun, Bingyuan Zhang & Fang Zheng

Cell Death & Disease 2018 9: 10.1038/s41419-018-0724-5

Abstract | Full Text

Phosphorylation of Parkin at serine 131 by p38 MAPK promotes mitochondrial dysfunction and neuronal death in mutant A53T α-synuclein model of Parkinson’s disease

Jialong Chen, Yixian Ren, Chen Gui, Menglan Zhao, Xian Wu et al.

Cell Death & Disease 2018 9: 10.1038/s41419-018-0722-7

Abstract | Full Text

Human iPSC-based models highlight defective glial and neuronal differentiation from neural progenitor cells in metachromatic leukodystrophy

Giacomo Frati, Marco Luciani, Vasco Meneghini, Silvia De Cicco, Marcus Ståhlman et al.

Cell Death & Disease 2018 9: 10.1038/s41419-018-0737-0

Abstract | Full Text

Increased levels of the long noncoding RNA, HOXA-AS3, promote proliferation of A549 cells

Hongyue Zhang, Ying Liu, Lixin Yan, Min Zhang, Xiufeng Yu et al.

Cell Death & Disease 2018 9: 10.1038/s41419-018-0725-4

Abstract | Full Text

Placental exosome-mediated Bta-miR-499-Lin28B/let-7 axis regulates inflammatory bias during early pregnancy

Gan Zhao, Chao Yang, Jing Yang, Pei Liu, Kangfeng Jiang et al.

Cell Death & Disease 2018 9: 10.1038/s41419-018-0713-8

Abstract | Full Text

Fas-L promotes the stem cell potency of adipose-derived mesenchymal cells

Inna Solodeev, Benjamin Meilik, Ilan Volovitz, Meirav Sela, Sharon Manheim et al.

Cell Death & Disease 2018 9: 10.1038/s41419-018-0702-y

Abstract | Full Text

Loss of Drosha underlies dopaminergic neuron toxicity in models of Parkinson’s disease

Ronglin Wang, Fangfang Lu, Gang Zhu, Dayun Feng, Tiejian Nie et al.

Cell Death & Disease 2018 9: 10.1038/s41419-018-0716-5

Abstract | Full Text

Histamine deficiency aggravates cardiac injury through miR-206/216b-Atg13 axis-mediated autophagic-dependant apoptosis

Suling Ding, Mieradilijiang Abudupataer, Zheliang Zhou, Jinmiao Chen, Hui Li et al.

Cell Death & Disease 2018 9: 10.1038/s41419-018-0723-6

Abstract | Full Text

RIP1 protects melanoma cells from apoptosis induced by BRAF/MEK inhibitors

Fu Xi Lei, Lei Jin, Xiao Ying Liu, Fritz Lai, Xu Guang Yan et al.

Cell Death & Disease 2018 9: 10.1038/s41419-018-0714-7

Abstract | Full Text

miR-16-5p inhibits chordoma cell proliferation, invasion and metastasis by targeting Smad3

Hongliang Zhang, Kang Yang, Tingting Ren, Yi Huang, Xiaodong Tang et al.

Cell Death & Disease 2018 9: 10.1038/s41419-018-0738-z

Abstract | Full Text

The transcription factor Zfp90 regulates the self-renewal and differentiation of hematopoietic stem cells

Ting Liu, Wei-xia Kong, Xiao-yi Tang, Man Xu, Qing-han Wang et al.

Cell Death & Disease 2018 9: 10.1038/s41419-018-0721-8

Abstract | Full Text

Inflammation, neurodegeneration and protein aggregation in the retina as ocular biomarkers for Alzheimer’s disease in the 3xTg-AD mouse model

Alfonso Grimaldi, Carlo Brighi, Giovanna Peruzzi, Davide Ragozzino, Valentina Bonanni et al.

Cell Death & Disease 2018 9: 10.1038/s41419-018-0740-5

Abstract | Full Text

Pharmacological inactivation of the PI3K p110δ prevents breast tumour progression by targeting cancer cells and macrophages

Evangelia Goulielmaki, Miriam Bermudez-Brito, Margarita Andreou, Niki Tzenaki, Maria Tzardi et al.

Cell Death & Disease 2018 9: 10.1038/s41419-018-0717-4

Abstract | Full Text

Molecular characterization and integrative genomic analysis of a panel of newly established penile cancer cell lines

Qiang-hua Zhou, Chuang-zhong Deng, Zai-shang Li, Jie-ping Chen, Kai Yao et al.

Cell Death & Disease 2018 9: 10.1038/s41419-018-0736-1

Abstract | Full Text

The natural compound GL22, isolated from Ganoderma mushrooms, suppresses tumor growth by altering lipid metabolism and triggering cell death

Ge Liu, Kai Wang, Shan Kuang, Ruobing Cao, Li Bao et al.

Cell Death & Disease 2018 9: 10.1038/s41419-018-0731-6

Abstract | Full Text

Cardiomyocyte-specific disruption of Cathepsin K protects against doxorubicin-induced cardiotoxicity

Rui Guo, Yinan Hua, Jun Ren, Karin E. Bornfeldt & Sreejayan Nair

Cell Death & Disease 2018 9: 10.1038/s41419-018-0727-2

Abstract | Full Text

Mesenchymal stromal cells-derived matrix Gla protein contribute to the alleviation of experimental colitis

Yuan Feng, Yan Liao, Weijun Huang, Xingqiang Lai, Jing Luo et al.

Cell Death & Disease 2018 9: 10.1038/s41419-018-0734-3

Abstract | Full Text

Dapsone protects brain microvascular integrity from high-fat diet induced LDL oxidation

Rui Zhan, Mingming Zhao, Ting Zhou, Yue Chen, Weiwei Yu et al.

Cell Death & Disease 2018 9: 10.1038/s41419-018-0739-y

Abstract | Full Text

Ablation of somatostatin cells leads to impaired pancreatic islet function and neonatal death in rodents

Na Li, Zhao Yang, Qing Li, Zhen Yu, Xu Chen et al.

Cell Death & Disease 2018 9: 10.1038/s41419-018-0741-4

Abstract | Full Text

Aberrant mannosylation profile and FTX/miR-342/ALG3-axis contribute to development of drug resistance in acute myeloid leukemia

Bing Liu, Xiaolu Ma, Qianqian Liu, Yang Xiao, Shimeng Pan et al.

Cell Death & Disease 2018 9: 10.1038/s41419-018-0706-7

Abstract | Full Text

The distinct role of strand-specific miR-514b-3p and miR-514b-5p in colorectal cancer metastasis

Lin-Lin Ren, Ting-Ting Yan, Chao-Qin Shen, Jia-Yin Tang, Xuan Kong et al.

Cell Death & Disease 2018 9: 10.1038/s41419-018-0732-5

Abstract | Full Text

Activation of neutral sphingomyelinase 2 by starvation induces cell-protective autophagy via an increase in Golgi-localized ceramide

Moon Jung Back, Hae Chan Ha, Zhicheng Fu, Jong Min Choi, Yongwei Piao et al.

Cell Death & Disease 2018 9: 10.1038/s41419-018-0709-4

Abstract | Full Text

DDX39 promotes hepatocellular carcinoma growth and metastasis through activating Wnt/β-catenin pathway

Tong Zhang, Zhenjiang Ma, Lijuan Liu, Jian Sun, Hui Tang et al.

Cell Death & Disease 2018 9: 10.1038/s41419-018-0591-0

Abstract | Full Text

Humanized mice reveal an essential role for human hepatocytes in the development of the liver immune system

Jinglong Guo, Yang Li, Yanhong Shan, Chang Shu, Feng Wang et al.

Cell Death & Disease 2018 9: 10.1038/s41419-018-0720-9

Abstract | Full Text

COMP-prohibitin 2 interaction maintains mitochondrial homeostasis and controls smooth muscle cell identity

Yiting Jia, Meili Wang, Chenfeng Mao, Fang Yu, Yingbao Wang et al.

Cell Death & Disease 2018 9: 10.1038/s41419-018-0703-x

Abstract | Full Text

Sorting nexin 10 controls mTOR activation through regulating amino-acid metabolism in colorectal cancer

Yunchen Le, Sulin Zhang, Jiahui Ni, Yan You, Kejing Luo et al.

Cell Death & Disease 2018 9: 10.1038/s41419-018-0719-2

Abstract | Full Text

Neutrophils induce macrophage anti-inflammatory reprogramming by suppressing NF-κB activation

John A. Marwick, Ross Mills, Oliver Kay, Kyriakos Michail, Jillian Stephen et al.

Cell Death & Disease 2018 9: 10.1038/s41419-018-0710-y

Abstract | Full Text

Decreased expression of ARHGAP15 promotes the development of colorectal cancer through PTEN/AKT/FOXO1 axis

Shengli Pan, Yingying Deng, Jun Fu, Yuhao Zhang, Zhijin Zhang et al.

Cell Death & Disease 2018 9: 10.1038/s41419-018-0707-6

Abstract | Full Text

Reduction of the ATPase inhibitory factor 1 (IF1) leads to visual impairment in vertebrates

Rebeca Martín-Jiménez, Danilo Faccenda, Emma Allen, Holly Beatrice Reichel, Laura Arcos et al.

Cell Death & Disease 2018 9: 10.1038/s41419-018-0578-x

Abstract | Full Text

NHERF1 inhibits beta-catenin-mediated proliferation of cervical cancer cells through suppression of alpha-actinin-4 expression

Qiqi Wang, Qiong Qin, Ran Song, Chunjuan Zhao, Hua Liu et al.

Cell Death & Disease 2018 9: 10.1038/s41419-018-0711-x

Abstract | Full Text

Succinate induces aberrant mitochondrial fission in cardiomyocytes through GPR91 signaling

Yi-Tong Lu, Lan-Zhu Li, Yi-Lin Yang, Xiaojian Yin, Qun Liu et al.

Cell Death & Disease 2018 9: 10.1038/s41419-018-0708-5

Abstract | Full Text

RAGE-dependent mitochondria pathway: a novel target of silibinin against apoptosis of osteoblastic cells induced by advanced glycation end products

Y. X. Mao, W. J. Cai, X. Y. Sun, P. P. Dai, X. M. Li et al.

Cell Death & Disease 2018 9: 10.1038/s41419-018-0718-3

Abstract | Full Text



Correction to: Long noncoding RNA TUG1 facilitates osteogenic differentiation of periodontal ligament stem cells via interacting with Lin28A

Qin He, Shuangyan Yang, Xiuge Gu, Mengying Li, Chunling Wang et al.

Cell Death & Disease 2018 9: 10.1038/s41419-018-0750-3

Abstract | Full Text

Correction to: TNF signaling and macrophages govern fin regeneration in zebrafish larvae

Mai Nguyen-Chi, Béryl Laplace-Builhé, Jana Travnickova, Patricia Luz-Crawford, Gautier Tejedor et al.

Cell Death & Disease 2018 9: 10.1038/s41419-018-0751-2

Abstract | Full Text

Correction to: JNK–NQO1 axis drives TAp73-mediated tumor suppression upon oxidative and proteasomal stress

A. Kostecka, A. Sznarkowska, K. Meller, P. Acedo, Y. Shi et al.

Cell Death & Disease 2018 9: 10.1038/s41419-018-0655-1

Abstract | Full Text

Correction to: JNK–NQO1 axis drives TAp73-mediated tumor suppression upon oxidative and proteasomal stress

A. Kostecka, A. Sznarkowska, K. Koczergo, P. Acedo, Y. Shi et al.

Cell Death & Disease 2018 9: 10.1038/s41419-018-0654-2

Abstract | Full Text



Challenging tumor resistance with less toxic, more effective drug combinations: an example from neuroblastoma

Alessandra Gambacurta & Giuseppe Raschellà

Cell Death & Disease 2018 9: 10.1038/s41419-018-0728-1

Abstract | Full Text

Review Article


Mechanism of neuroprotection by trehalose: controversy surrounding autophagy induction

He-Jin Lee, Ye-Seul Yoon & Seung-Jae Lee

Cell Death & Disease 2018 9: 10.1038/s41419-018-0749-9

Abstract | Full Text

Hedgehog signalling in the tumourigenesis and metastasis of osteosarcoma, and its potential value in the clinical therapy of osteosarcoma

Zhihong Yao, Lei Han, Yongbin Chen, Fei He, Bin Sun et al.

Cell Death & Disease 2018 9: 10.1038/s41419-018-0647-1

Abstract | Full Text

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