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Nature Volume 559 Issue 7712
This Week  
Brain-protein structure could point way to safer prescription drugs
Science must help to make city living sustainable
A welcome from the new Nature editor
Magdalena Skipper
Read the latest science news from A*STAR, the Agency for Science, Technology and Research, Singapore's leading research organization
Recent stories:
World View  
Advance the ecosystem approach in cities
Xuemei Bai
Research Highlights  
This issue's Research Highlights
Selections from the scientific literature.
Seven Days  
Microscope damage, reef recovery and disappearing trees
News in Focus
Gigantic study of Chinese babies yields slew of health data
David Cyranoski
There’s no limit to longevity, says study that revives human lifespan debate
Elie Dolgin
Cyprus asserts itself as regional hub for climate-change research
Anita Makri
Delays mount for NASA’s $8-billion Hubble successor
Alexandra Witze
Europe’s biggest research fund cracks down on ‘ethics dumping’
Linda Nordling
The labs growing human embryos for longer than ever before
Helen Shen
Nature Podcast 05 July 2018
This week, investigating the koala genome, the issues facing LGBTQ+ researchers, and a DNA-based neural network.
A better measure of research from the global south
Jean Lebel, Robert McLean
LGBTQ scientists are still left out
Jon Freeman
Books and Arts  
UNESCO’s troubled drive for peace through science and culture
Andrew Robinson
The backbone begins: a spine-tingling story
Chris Lowe
Personalized medicine should not be restricted to the wealthy
Colum P. Dunne, Suzanne S. Dunne
Italy is squeezing out wet biology research
Davide Zannoni
University came to the rescue of accused researcher
Roberto Caminiti
Evaluation woes: we’re on it, responds DORA
Anna Hatch, Stephen Curry
Speaking in code: how to program by voice
Anna Nowogrodzki
Harness the power of groups to beat the ‘PhD blues’
Karra Harrington

Matt Thompson
KACST Impact

KACST Impact is a new online publication highlighting the latest cutting edge scientific research conducted at King Abdulaziz City for Science and Technology (KACST) that features various stories ranging from exciting new scientific finds to the commercialization of innovative discoveries.

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Mechanism for remodelling of the cell cycle checkpoint protein MAD2 by the ATPase TRIP13
Structural analysis demonstrates how TRIP13 and p31comet disassemble the mitotic checkpoint complex.
Claudio Alfieri, Leifu Chang, David Barford
Targeting STING with covalent small-molecule inhibitors
The discovery and characterization of small-molecule antagonists that inhibit the stimulator of interferon genes (STING) protein may help to develop therapies for the treatment of autoinflammatory disease.
Simone M. Haag, Muhammet F. Gulen, Luc Reymond et al.
Coronary artery development, one cell at a time
An analysis of gene-expression patterns in single cells provides detailed insights into the developmental processes that lead to maturation of the coronary arteries.
Arndt F. Siekmann
Structure of the origin recognition complex bound to DNA replication origin
The cryo-EM structure of the yeast origin recognition complex (ORC) bound to a 72-base-pair origin DNA sequence provides insights into the basis of the origin selection mechanism.
Ningning Li, Wai Hei Lam, Yuanliang Zhai et al.
Species-specific activity of antibacterial drug combinations
Screening pairwise combinations of antibiotics and other drugs against three bacterial pathogens reveals that antagonistic and synergistic drug–drug interactions are specific to microbial species and strains.
Ana Rita Brochado, Anja Telzerow, Jacob Bobonis et al.
Evolution of cooperation in stochastic games
Cooperation is more likely to evolve in a public-goods-distribution game when payoffs can change between rounds so that the stakes increase when players cooperate and decrease when players defect.
Christian Hilbe, Štěpán Šimsa, Krishnendu Chatterjee et al.
Suppression of insulin feedback enhances the efficacy of PI3K inhibitors
Benjamin D. Hopkins, Chantal Pauli, Xing Du et al.
CRISPR screens identify genomic ribonucleotides as a source of PARP-trapping lesions
Mutations in all three genes encoding ribonuclease H2 sensitize cells to poly(ADP–ribose) polymerase inhibitors by compromising ribonucleotide excision repair.
Michal Zimmermann, Olga Murina, Martin A. M. Reijns et al.
The purinergic receptor P2RX7 directs metabolic fitness of long-lived memory CD8+ T cells
Activation of P2RX7 receptors by extracellular ATP is required for the generation, maintenance and function of central and tissue-resident CD8+ memory T cells.
Henrique Borges da Silva, Lalit K. Beura, Haiguang Wang et al.
Single-cell analysis of early progenitor cells that build coronary arteries
During development, new arteries can arise from pre-existing veins; the cell fate switch involved occurs gradually and before the onset of blood flow in mouse embryo hearts.
Tianying Su, Geoff Stanley, Rahul Sinha et al.
Speciation far from the madding crowd
New species of marine fishes are found to emerge at a faster rate in high-latitude oceans, which have lower densities of species, than in the species-rich tropics. Are the tropics too crowded for new species to take hold?
Arne O. Mooers, Dan A. Greenberg
An inverse latitudinal gradient in speciation rate for marine fishes
Contrary to previous hypotheses, high-latitude fish lineages form new species at much faster rates than their tropical counterparts especially in geographical regions that are characterized by low surface temperatures and high endemism.
Daniel L. Rabosky, Jonathan Chang, Pascal O. Title et al.
Kinase-controlled phase transition of membraneless organelles in mitosis
The dual-specificity kinase DYRK3 acts as a central ‘dissolvase’, mediating the phase transitions of several types of membraneless organelles during mitosis.
Arpan Kumar Rai, Jia-Xuan Chen, Matthias Selbach et al.
Scaling up molecular pattern recognition with DNA-based winner-take-all neural networks
DNA-strand-displacement reactions are used to implement a neural network that can distinguish complex and noisy molecular patterns from a set of nine possibilities—an improvement on previous demonstrations that distinguished only four simple patterns.
Kevin M. Cherry, Lulu Qian
Self-organizing multicellular structures designed using synthetic biology
Synthetic genetic circuits can induce cells to form simple 3D structures reminiscent of those generated during early embryonic development. This advance will help engineers build tissues that have desirable structures.
Jesse Tordoff, Ron Weiss
Synchronous tropical and polar temperature evolution in the Eocene
A 26-million-year record of equatorial sea surface temperatures reveals synchronous changes of tropical and polar temperatures during the Eocene epoch forced by variations in concentrations of atmospheric carbon dioxide, with a constant degree of polar amplification.
Margot J. Cramwinckel, Matthew Huber, Ilja J. Kocken et al.
News & Views  
Doubt cast on how the pace of global glacial erosion responds to climate cooling
Eric Kirby
Actin proteins assemble to protect the genome
Vassilis Roukos
Key receptor involved in neuronal signalling visualized
Erwin Sigel
A molecular signature for social isolation identified in the brain
Noga Zilkha, Tali Kimchi
50 & 100 years ago
General relativity verified by a triple-star system
Clifford M. Will
Unexpected cell population gives fat a brake
David A. Guertin
Taking bioengineered heart valves from faulty to functional
Craig A. Simmons
Structural insights into G-protein-coupled receptor allostery
High-resolution structural studies of GPCRs have led to insights into the role of allostery in GPCR-mediated signal transduction.
David M. Thal, Alisa Glukhova, Patrick M. Sexton et al.
Nuclear F-actin and myosins drive relocalization of heterochromatic breaks
Relocalization of heterochromatic double-strand breaks to the nuclear periphery in Drosophila cells occurs via directed motions driven by nuclear actin filaments and myosins activated by the Smc5/6 complex.
Christopher P. Caridi, Carla D’Agostino, Taehyun Ryu et al.
Nuclear ARP2/3 drives DNA break clustering for homology-directed repair
Polymerization of actin in the cell nucleus, promoted by the ARP2/3 complex, drives the clustering of double-strand DNA breaks into nuclear compartments where they can undergo homology-directed repair.
Benjamin R. Schrank, Tomas Aparicio, Yinyin Li et al.
Structure of a human synaptic GABAA receptor
The cryo-electron microscopy structure of the type A GABA receptor bound to GABA and the benzodiazepine site antagonist flumazenil reveals structural mechanisms that underlie intersubunit interactions and ligand selectivity of the receptor.
Shaotong Zhu, Colleen M. Noviello, Jinfeng Teng et al.
Universality of free fall from the orbital motion of a pulsar in a stellar triple system
The accelerations of a pulsar and a white dwarf in a three-star system differ by at most a few parts per million, providing a much improved constraint on the universality of free fall.
Anne M. Archibald, Nina V. Gusinskaia, Jason W. T. Hessels et al.
Multifunctional ferrofluid-infused surfaces with reconfigurable multiscale topography
By infusing a ferrofluid into a microstructured matrix and applying a magnetic field, dynamic, multiscale topographical reconfigurations emerge, enabling functions such as colloidal self-assembly, switchable adhesion and friction, and biofilm removal.
Wendong Wang, Jaakko V. I. Timonen, Andreas Carlson et al.
Decarboxylative sp3 C–N coupling via dual copper and photoredox catalysis
The synergistic combination of copper catalysis and photoredox catalysis forms sp3 C–N bonds in a rapid, room-temperature coupling protocol with high efficiencies and regioselectivities and a broad substrate scope.
Yufan Liang, Xiaheng Zhang, David W. C. MacMillan
Spatial correlation bias in late-Cenozoic erosion histories derived from thermochronology
Reported acceleration of erosion in mountainous landscapes during the late Cenozoic is the result of combining thermochronology data with disparate exhumation histories, thereby converting spatial variations in erosion rates into temporal increases.
Taylor F. Schildgen, Pieter A. van der Beek, Hugh D. Sinclair et al.
Low-temperature crystallization of granites and the implications for crustal magmatism
Thermobarometry and diffusion modelling in quartz crystals show that some granites may crystallize at much lower temperatures than previously thought, possibly explaining observations of cold magma storage.
Michael R. Ackerson, B. O. Mysen, N. D. Tailby et al.
Hippocampal neurogenesis confers stress resilience by inhibiting the ventral dentate gyrus
Adult neurogenesis in the hippocampus confers resilience to chronic stress in mice by inhibiting the activity of mature granule cells in the ventral dentate gyrus.
Christoph Anacker, Victor M. Luna, Gregory S. Stevens et al.
A stromal cell population that inhibits adipogenesis in mammalian fat depots
Single-cell transcriptomics reveals that, in mice and humans, a population of cells in the stromal vascular fraction of adipose tissue regulates adipogenesis by suppressing adipocyte formation in a paracrine manner.
Petra C. Schwalie, Hua Dong, Magda Zachara et al.
Parasitic helminths induce fetal-like reversion in the intestinal stem cell niche
Larvae of the parasitic helminth Heligmosomoides polygyrus induce granuloma formation and a fetal-like developmental program in granuloma-associated crypts of infected adult mice.
Ysbrand M. Nusse, Adam K. Savage, Pauline Marangoni et al.
Induction of innate immune memory via microRNA targeting of chromatin remodelling factors
The microRNAs miR-221 and miR-222 regulate the reprogramming of macrophages during the development of lipopolysaccharide tolerance, and increased expression of these microRNAs is associated with immunosuppression and poor prognosis in patients with sepsis.
John J. Seeley, Rebecca G. Baker, Ghait Mohamed et al.
OTULIN limits cell death and inflammation by deubiquitinating LUBAC
OTULIN, which removes ubiquitin chains deposited by LUBAC, promotes LUBAC activity by preventing its auto-ubiquitination, thereby supporting normal mouse embryo development and preventing pro-inflammatory cell death in adult mice.
Klaus Heger, Katherine E. Wickliffe, Ada Ndoja et al.
Acquired resistance to IDH inhibition through trans or cis dimer-interface mutations
A new mechanism of acquired clinical resistance in two patients with acute myeloid leukaemia driven by mutant IDH2 is described, in which a second-site mutation on the wild-type allele induces therapeutic resistance to IDH2 inhibitors.
Andrew M. Intlekofer, Alan H. Shih, Bo Wang et al.
The helicase Ded1p controls use of near-cognate translation initiation codons in 5′ UTRs
The helicase Ded1p associates with the pre-initiation complex and influences translation from near-cognate initiation codons by controlling the levels of mRNA secondary structure in 5′ untranslated regions.
Ulf-Peter Guenther, David E. Weinberg, Meghan M. Zubradt et al.
Cryo-EM structure of an essential Plasmodium vivax invasion complex
Structural studies show that conserved residues in Plasmodium vivax reticulocyte-binding protein 2b determine interactions with transferrin receptor 1 that are essential for host invasion, suggesting avenues for designing vaccines that work across P. vivax strains.
Jakub Gruszczyk, Rick K. Huang, Li-Jin Chan et al.
Amendments & Corrections
Publisher Correction: Adolescence and the next generation
George C. Patton, Craig A. Olsson, Vegard Skirbekk et al.
Author Correction: The axolotl genome and the evolution of key tissue formation regulators
Sergej Nowoshilow, Siegfried Schloissnig, Ji-Feng Fei et al.
Addendum: Copper-catalysed enantioselective stereodivergent synthesis of amino alcohols
Shi-Liang Shi, Zackary L. Wong, Stephen L. Buchwald


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