If you are still having problems viewing this message, please click here for additional help.

Nature Reviews Genetics

Do you have a career question? 

The Naturejobs podcast features one-on-one Q&As, panel discussions and other exclusive content to help scientists with their careers. Hosted on the Naturejobs blog, the podcast is also available on iTunes and Soundcloud. 

Listen today! 

August 2018 Volume 19, Issue 8

Research Highlights
Focus on Autoimmune Disease from Nature Immunology

A series of Reviews specially commissioned by Nature Immunology discuss the genetic, environmental, microbial and cellular factors underpinning autoimmune disease as well as highlight avenues for therapeutic intervention.

Access free online

Produced with support from Janssen Research & Development

Nature Reviews Reader Survey

At Nature Reviews we are continually looking for ways to ensure we meet our readers' needs. Your responses to this short survey will give us insight into how our content may be improved.

Get started here.

Research Highlights


Breakdancing on actin    p469
Paulina Strzyz

Two independent studies now show that polymerization of branched actin at DNA double-strand breaks (DSBs) mediates chromatin dynamics associated with homology-directed repair and is required for a robust and error-free DSB repair process.


Chromosome interaction hubs around nuclear bodies    pp470 - 471
Linda Koch

A paper in Cell presents split–pool recognition of interactions by tag extension (SPRITE), a method that enables the identification of multiple, simultaneously occurring DNA and RNA interactions genome-wide within the nucleus.


Refining the splice region    pp470 - 471
Rebecca Furlong

A study in Genome Research reports the impact of genetic variation near splice sites on human disease and may help prioritize and functionally interpret newly identified variants.


Prospecting for pluripotency    p471
Dorothy Clyde

Unlike most organisms, planaria maintain pluripotent stem cells (PSCs) beyond embryogenesis. A new study reports the prospective identification and isolation of a neoblast subpopulation containing adult PSCs, characterization of which should help uncover the mechanisms underlying pluripotency and tissue regeneration.


All eyes on rapid adaptive evolution    p472
Linda Koch

A new study reveals that DNA methylation-mediated repression of gene expression regulates early eye development in blind cave morphs of Astyanax mexicanus.


What makes us human?    p472
Linda Koch

A publication in Science reports the sequencing, assembly and comparative analysis of new and improved great ape genomes and provides a stepping stone for the identification of genetic variation specific to humans.


Nature Reviews Genetics
JOBS of the week
IBMS Seeking Assistant / Associate / Full Professor
The Institute of Basic Medical Sciences (IBMS)
Associate Senior Lecturer
Swedish University of Agricultural Sciences (SLU)
Postdoctoral position at the NIH
National Institutes of Health (NIH)
Multiple Faculty Positions
The Institute of Health Sciences, ─░stanbul, Turkey
Postdoctoral Research Associate
University of Minnesota
More Science jobs from
Nature Reviews Genetics
Short Course on the Genetics of Addiction
Bar Harbor, USA
More science events from



A-to-I RNA editing — immune protector and transcriptome diversifier    pp473 - 490
Eli Eisenberg & Erez Y. Levanon

Next-generation sequencing technologies have enabled the comparison of editomes from multiple individuals and from multiple species. The results have changed our understanding of the extent and distribution of A-to-I editing and its role in evolution and disease.


From genome-wide associations to candidate causal variants by statistical fine-mapping    pp491 - 504
Daniel J. Schaid, Wenan Chen & Nicholas B. Larson

Fine-mapping is the process by which a trait-associated region from a genome-wide association study (GWAS) is analysed to identify the particular genetic variants that are likely to causally influence the examined trait. This Review discusses the diverse statistical approaches to fine-mapping and their foundations, strengths and limitations, including integration of trans-ethnic human population data and functional annotations.


The rice genome revolution: from an ancient grain to Green Super Rice    pp505 - 517
Rod A. Wing, Michael D. Purugganan & Qifa Zhang

Genomic technologies are helping researchers to understand the natural genetic variation that exists in wild and cultivated rice populations. Harnessing this genetic variation will be key to developing Green Super Rice varieties with high yield and low environmental costs.


Controlling nuclear RNA levels    pp518 - 529
Manfred Schmid & Torben Heick Jensen

RNA is controlled at various stages of transcription and processing to achieve appropriate gene regulation. Whereas much research has focused on the cytoplasmic control of RNA levels, this Review discusses our emerging appreciation of the importance of nuclear RNA regulation, including the molecular machinery involved in nuclear RNA decay, how functional RNAs bypass degradation and roles for nuclear RNA decay in physiology and disease.


Nature Briefing is an essential round-up of science news, opinion and analysis, free in your inbox every weekday. With Nature Briefing, we'll keep you updated on the latest research, so you can focus on yours.

Click here to sign up.
nature events
Natureevents is a fully searchable, multi-disciplinary database designed to maximise exposure for events organisers. The contents of the Natureevents Directory are now live. The digital version is available here.
Find the latest scientific conferences, courses, meetings and symposia on natureevents.com. For event advertising opportunities across the Nature Publishing Group portfolio please contact natureevents@nature.com
More Nature Events

You have been sent this Table of Contents Alert because you have opted in to receive it. You can change or discontinue your e-mail alerts at any time, by modifying your preferences on your nature.com account at: www.nature.com/myaccount
(You will need to log in to be recognised as a nature.com registrant)

For further technical assistance, please contact our registration department

For print subscription enquiries, please contact our subscription department

For other enquiries, please contact our customer feedback department

Springer Nature | One New York Plaza, Suite 4500 | New York | NY 10004-1562 | USA

Springer Nature's worldwide offices:
London - Paris - Munich - New Delhi - Tokyo - Melbourne
San Diego - San Francisco - Washington - New York - Boston

Macmillan Publishers Limited is a company incorporated in England and Wales under company number 785998 and whose registered office is located at The Campus, 4 Crinan Street, London, N1 9XW.

© 2018 Macmillan Publishers Limited, part of Springer Nature. All Rights Reserved.

Springer Nature