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TABLE OF CONTENTS

August 2018 Volume 14, Issue 8

Research Highlights
News & Views
Perspectives
Brief Communications
Articles
 
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Research Highlights

 

Crowd control    p745
Grant Miura
doi:10.1038/s41589-018-0109-1

Caught in the act    p745
Karin Kuehnel
doi:10.1038/s41589-018-0110-8

Dopamine gets lit    p745
Mirella Bucci
doi:10.1038/s41589-018-0111-7

3D interaction hubs    p745
Yiyun Song
doi:10.1038/s41589-018-0112-6

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News & Views

 

Unraveling the rewired network    pp746 - 747
Vinayak Palve, Brent M. Kuenzi & Uwe Rix
doi:10.1038/s41589-018-0083-7

Antigen processing movers and shakers    pp747 - 748
Tim Elliott
doi:10.1038/s41589-018-0106-4

A remote control for switching    pp749 - 750
Marc Vendrell
doi:10.1038/s41589-018-0107-3

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Perspectives

 

The evolving interface between synthetic biology and functional metagenomics    pp752 - 759
Eric van der Helm, Hans J. Genee & Morten O. A. Sommer
doi:10.1038/s41589-018-0100-x

Synthetic biology is enabling functional metagenomics by providing genetic circuits to identify new pathways that, in turn, facilitate design of new biosensors and synthetic systems.

 

 

Brief Communications

 

Sarpagan bridge enzyme has substrate-controlled cyclization and aromatization modes    pp760 - 763
Thu-Thuy T. Dang, Jakob Franke, Ines Soares Teto Carqueijeiro, Chloe Langley, Vincent Courdavault et al.
doi:10.1038/s41589-018-0078-4

Three homologous cytochrome P450s from monoterpene indole alkaloid-producing plants enable the identification of sarpagan bridge enzyme, which catalyzes either cyclization or aromatization to yield sarpagan or β-carboline alkaloids, respectively.

 

 

Optical control of L-type Ca2+ channels using a diltiazem photoswitch    pp764 - 767
Timm Fehrentz, Florian M. E. Huber, Nina Hartrampf, Tobias Bruegmann, James A. Frank et al.
doi:10.1038/s41589-018-0090-8

A photoswitchable probe to control Ca2+ influx through L-type Ca2+ channels is useful in pancreatic β cells and can be employed to modulate beating rate in explanted hearts.

 

 

Articles

 

Kinome rewiring reveals AURKA limits PI3K-pathway inhibitor efficacy in breast cancer    pp768 - 777
Hayley J. Donnella, James T. Webber, Rebecca S. Levin, Roman Camarda, Olga Momcilovic et al.
doi:10.1038/s41589-018-0081-9

Proteomic mapping of dynamic changes in kinase signaling after drug treatment identifies that AURKA inhibition is required for drug sensitivity, representing a new co-targeting opportunity with PI3K, AKT, or mTOR inhibitors in breast cancer.

 

 

Potent and specific Atg8-targeting autophagy inhibitory peptides from giant ankyrins    pp778 - 787
Jianchao Li, Ruichi Zhu, Keyu Chen, Hui Zheng, Hongyu Zhao et al.
doi:10.1038/s41589-018-0082-8

Potent pan-Atg8 or GABARAP-selective inhibitory peptides derived from giant neuronal ankyrin-B and -G effectively block autophagy in cell cultures and in C. elegans spatiotemporally.

 

 

Scavenging of superoxide by a membrane-bound superoxide oxidase    pp788 - 793
Camilla A. K. Lundgren, Dan Sjöstrand, Olivier Biner, Matthew Bennett, Axel Rudling et al.
doi:10.1038/s41589-018-0072-x

The membrane-bound enzyme CybB can directly oxidize superoxide to molecular oxygen and transfer the sequestered electrons to ubiquinone in vitro, providing a mechanism for superoxide scavenging distinct from that of superoxide dismutase.

 

 

Metabolic engineering of a carbapenem antibiotic synthesis pathway in Escherichia coli    pp794 - 800
Helena Shomar, Sophie Gontier, Niels J. F. van den Broek, Héctor Tejeda Mora, Marek J. Noga et al.
doi:10.1038/s41589-018-0084-6

Efficient production of a simple carbapenem antibiotic in Escherichia coli is achieved by a combination of feedback-resistant enzymes for increased precursor biosynthesis and inhibition of fatty acid synthesis for tolerance toward the toxic product.

 

 

Rab11 activity and PtdIns(3)P turnover removes recycling cargo from endosomes    pp801 - 810
Carlo Cosimo Campa, Jean Piero Margaria, Abhishek Derle, Marco Del Giudice, Maria Chiara De Santis et al.
doi:10.1038/s41589-018-0086-4

A Rab11 FRET biosensor reveals a spatiotemporal interplay between Rab11 and PtdIns(3)P turnover during the removal of recycling cargo from the endosome.

 

 

Peptide exchange on MHC-I by TAPBPR is driven by a negative allostery release cycle    pp811 - 820
Andrew C. McShan, Kannan Natarajan, Vlad K. Kumirov, David Flores-Solis, Jiansheng Jiang et al.
doi:10.1038/s41589-018-0096-2

Use of NMR to monitor MHC-I dynamics upon binding to the MHC-I chaperone TAPBPR explains the selection of optimal peptide sequences and release of the chaperone from the ternary peptide-MHC-I–TAPBPR complex.

 

 

Designing microbial consortia with defined social interactions    pp821 - 829
Wentao Kong, David R. Meldgin, James J. Collins & Ting Lu
doi:10.1038/s41589-018-0091-7

Synthetic microbial consortia were engineered as experimental models of bacterial interactions within ecosystems, and mathematical models of their behavior were used to design more complex microbial systems with additional interactions.

 

 

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