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TABLE OF CONTENTS

August 2018 Volume 21, Issue 8

News & Views
Articles
Resources
Amendments & Corrections
 
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News & Views

 

Does predictive coding have a future?    pp1019 - 1021
Karl Friston
doi:10.1038/s41593-018-0200-7

FRETting over postsynaptic PKC signaling    pp1021 - 1022
Mark L. Dell’Acqua & Kevin M. Woolfrey
doi:10.1038/s41593-018-0190-5

The diverse culinary habits of microglia    pp1023 - 1025
Staci D. Bilbo
doi:10.1038/s41593-018-0196-z

Disease strays to evolution’s bounds    pp1025 - 1026
Rosalyn J. Moran
doi:10.1038/s41593-018-0199-9

Nature Neuroscience
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Articles

 

PKCα integrates spatiotemporally distinct Ca2+ and autocrine BDNF signaling to facilitate synaptic plasticity    pp1027 - 1037
Lesley A Colgan, Mo Hu, Jaime A. Misler, Paula Parra-Bueno, Corey M. Moran et al.
doi:10.1038/s41593-018-0184-3

Through the development of novel PKC biosensors, the authors describe how PKCα, but not other classical isozymes, facilitates plasticity in dendritic regions through the integration of recent synaptic plasticity with current, local synaptic input.

 

Pathogenic tau-induced piRNA depletion promotes neuronal death through transposable element dysregulation in neurodegenerative tauopathies    pp1038 - 1048
Wenyan Sun, Hanie Samimi, Maria Gamez, Habil Zare & Bess Frost
doi:10.1038/s41593-018-0194-1

Transposable elements, or ‘jumping genes’, constitute ~45% of the human genome. Sun et. al. report that jumping gene dysregulation is a pharmacologically targetable driver of cell death in neurodegenerative tauopathies, including Alzheimer’s disease.

 

Epigenetic regulation of brain region-specific microglia clearance activity    pp1049 - 1060
Pinar Ayata, Ana Badimon, Hayley J. Strasburger, Mary Kaye Duff, Sarah E. Montgomery et al.
doi:10.1038/s41593-018-0192-3

Microglia clearance activity in adult brain is regulated epigenetically and region-specifically to match neuronal attrition rates. Uncoupling this activity from neural apoptosis leads to aberrant microglia activation & neurodegenerative-like changes.

 

The maternal vaginal microbiome partially mediates the effects of prenatal stress on offspring gut and hypothalamus    pp1061 - 1071
Eldin Jašarević, Christopher D. Howard, Kathleen Morrison, Ana Misic, Tiffany Weinkopff et al.
doi:10.1038/s41593-018-0182-5

Maternal stress during pregnancy is a risk factor for neurodevelopmental disorders. Jasarevic and colleagues show that the maternal vaginal microbiota partially mediates the lasting effects of prenatal stress on the gut and hypothalamus in mice.

 

Dopamine neurons create Pavlovian conditioned stimuli with circuit-defined motivational properties    pp1072 - 1083
Benjamin T. Saunders, Jocelyn M. Richard, Elyssa B. Margolis & Patricia H. Janak
doi:10.1038/s41593-018-0191-4

By pairing cues with brief activation of dopamine neurons in absence of reward, the authors reveal elemental behaviors conditioned by dopamine, showing VTA underlies generation of incentive value and SNc supports conditioned movement invigoration.

 

Parallel circuits from the bed nuclei of stria terminalis to the lateral hypothalamus drive opposing emotional states    pp1084 - 1095
William J. Giardino, Ada Eban-Rothschild, Daniel J. Christoffel, Shi-Bin Li, Robert C. Malenka et al.
doi:10.1038/s41593-018-0198-x

Using genetically encoded physiological tools for monitoring, manipulating, and mapping discrete neural circuits, Giardino et al. characterize 2 discrete amygdala→hypothalamus pathways that promote opposite behavioral responses to emotional stimuli.

 

Principles governing the integration of landmark and self-motion cues in entorhinal cortical codes for navigation    pp1096 - 1106
Malcolm G. Campbell, Samuel A. Ocko, Caitlin S. Mallory, Isabel I. C. Low, Surya Ganguli et al.
doi:10.1038/s41593-018-0189-y

Using a combination of in vivo recording and theoretical modeling, Campbell et al. develop a framework for understanding the integration of self-motion and landmark cues in entorhinal cortex and demonstrate that these principles extend to behavior.

 

Fragility and volatility of structural hubs in the human connectome    pp1107 - 1116
Leonardo L. Gollo, James A. Roberts, Vanessa L. Cropley, Maria A. Di Biase, Christos Pantelis et al.
doi:10.1038/s41593-018-0188-z

Gollo et al. introduce random ‘mutations’ to the human connectome to study the trade-off between complexity vs. parsimony. The cortical hubs that are most fragile to these perturbations show the strongest loss of gray matter volume in schizophrenia.

 

Resources

 

Developmental and genetic regulation of the human cortex transcriptome illuminate schizophrenia pathogenesis    pp1117 - 1125
Andrew E. Jaffe, Richard E. Straub, Joo Heon Shin, Ran Tao, Yuan Gao et al.
doi:10.1038/s41593-018-0197-y

The authors surveyed gene expression across cortical development and in individuals with schizophrenia. Three-fold more risk variants influenced expression than known. Risk genes showed developmental regulation, while diagnosis changes implicated largely treatment effects.

 

Cell-specific histone modification maps in the human frontal lobe link schizophrenia risk to the neuronal epigenome    pp1126 - 1136
Kiran Girdhar, Gabriel E. Hoffman, Yan Jiang, Leanne Brown, Marija Kundakovic et al.
doi:10.1038/s41593-018-0187-0

This PsychENCODE resource presents 157 reference maps for open-chromatin-associated histone methylation and acetylation in prefrontal and anterior cingulate cortex, linking the neuronal epigenome to the genetic risk architecture of schizophrenia.

 

Amendments & Corrections

 

Author Correction: Selective synaptic remodeling of amygdalocortical connections associated with fear memory    p1137
Yang Yang, Dan-qian Liu, Wei Huang, Juan Deng, Yangang Sun et al.
doi:10.1038/s41593-018-0180-7

Author Correction: Microglial immune checkpoint mechanisms    p1137
Aleksandra Deczkowska, Ido Amit & Michal Schwartz
doi:10.1038/s41593-018-0186-1

Publisher Correction: TDP-43 gains function due to perturbed autoregulation in a Tardbp knock-in mouse model of ALS-FTD    p1138
Matthew A. White, Eosu Kim, Amanda Duffy, Robert Adalbert, Benjamin U. Phillips et al.
doi:10.1038/s41593-018-0160-y

Publisher Correction: Thalamic projections sustain prefrontal activity during working memory maintenance    p1138
Scott S Bolkan, Joseph M Stujenske, Sebastien Parnaudeau, Timothy J Spellman, Caroline Rauffenbart et al.
doi:10.1038/s41593-018-0132-2

Publisher Correction: Learning by neural reassociation    p1138
Matthew D. Golub, Patrick T. Sadtler, Emily R. Oby, Kristin M. Quick, Stephen I. Ryu et al.
doi:10.1038/s41593-018-0185-2

Publisher Correction: Social deficits in Shank3-deficient mouse models of autism are rescued by histone deacetylase (HDAC) inhibition    p1139
Luye Qin, Kaijie Ma, Zi-Jun Wang, Zihua Hu, Emmanuel Matas et al.
doi:10.1038/s41593-018-0165-6

Publisher Correction: Mutations in Vps15 perturb neuronal migration in mice and are associated with neurodevelopmental disease in humans    p1139
Thomas Gstrein, Andrew Edwards, Anna Přistoupilová, Ines Leca, Martin Breuss et al.
doi:10.1038/s41593-018-0170-9

Publisher Correction: N6-methyladenosine RNA modification regulates embryonic neural stem cell self-renewal through histone modifications    p1139
Yang Wang, Yue Li, Minghui Yue, Jun Wang, Sandeep Kumar et al.
doi:10.1038/s41593-018-0169-2

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