If you are still having problems viewing this message, please click here for additional help.

Nature Neuroscience

Do you have a career question? 

The Naturejobs podcast features one-on-one Q&As, panel discussions and other exclusive content to help scientists with their careers. Hosted on the Naturejobs blog, the podcast is also available on iTunes and Soundcloud. 

Listen today!

August 2018 Volume 21, Issue 8

News & Views
Amendments & Corrections
Focus on Autoimmune Disease from Nature Immunology

A series of Reviews specially commissioned by Nature Immunology discuss the genetic, environmental, microbial and cellular factors underpinning autoimmune disease as well as highlight avenues for therapeutic intervention. 

Access free online

Produced with support from Janssen Research & Development

2018 longlist - see the full line up

The nominations for the 2018 Nature Research Awards for Inspiring Science and Innovating Science are in. 

See who's been long listed here >

In partnership with The Estée Lauder Companies.

News & Views


Does predictive coding have a future?    pp1019 - 1021
Karl Friston

FRETting over postsynaptic PKC signaling    pp1021 - 1022
Mark L. Dell’Acqua & Kevin M. Woolfrey

The diverse culinary habits of microglia    pp1023 - 1025
Staci D. Bilbo

Disease strays to evolution’s bounds    pp1025 - 1026
Rosalyn J. Moran

Nature Neuroscience
JOBS of the week
Open Faculty Positions
Okinawa Institute of Science and Technology (OIST)
Postdoctoral Fellows and Research Scientist
Boston Children’s Hospital / Harvard Medical School
Psychology Clinical Jr. Faculty
Harvard University
Multiple Faculty Positions at ShanghaiTech University
ShanghaiTech University
Excellence in Science PhD Scholarship Award in Neuroscience
UTS - University Of Technology Sydney
More Science jobs from
Nature Neuroscience
Leuven, Belgium
More science events from



PKCα integrates spatiotemporally distinct Ca2+ and autocrine BDNF signaling to facilitate synaptic plasticity    pp1027 - 1037
Lesley A Colgan, Mo Hu, Jaime A. Misler, Paula Parra-Bueno, Corey M. Moran et al.

Through the development of novel PKC biosensors, the authors describe how PKCα, but not other classical isozymes, facilitates plasticity in dendritic regions through the integration of recent synaptic plasticity with current, local synaptic input.


Pathogenic tau-induced piRNA depletion promotes neuronal death through transposable element dysregulation in neurodegenerative tauopathies    pp1038 - 1048
Wenyan Sun, Hanie Samimi, Maria Gamez, Habil Zare & Bess Frost

Transposable elements, or ‘jumping genes’, constitute ~45% of the human genome. Sun et. al. report that jumping gene dysregulation is a pharmacologically targetable driver of cell death in neurodegenerative tauopathies, including Alzheimer’s disease.


Epigenetic regulation of brain region-specific microglia clearance activity    pp1049 - 1060
Pinar Ayata, Ana Badimon, Hayley J. Strasburger, Mary Kaye Duff, Sarah E. Montgomery et al.

Microglia clearance activity in adult brain is regulated epigenetically and region-specifically to match neuronal attrition rates. Uncoupling this activity from neural apoptosis leads to aberrant microglia activation & neurodegenerative-like changes.


The maternal vaginal microbiome partially mediates the effects of prenatal stress on offspring gut and hypothalamus    pp1061 - 1071
Eldin Jašarević, Christopher D. Howard, Kathleen Morrison, Ana Misic, Tiffany Weinkopff et al.

Maternal stress during pregnancy is a risk factor for neurodevelopmental disorders. Jasarevic and colleagues show that the maternal vaginal microbiota partially mediates the lasting effects of prenatal stress on the gut and hypothalamus in mice.


Dopamine neurons create Pavlovian conditioned stimuli with circuit-defined motivational properties    pp1072 - 1083
Benjamin T. Saunders, Jocelyn M. Richard, Elyssa B. Margolis & Patricia H. Janak

By pairing cues with brief activation of dopamine neurons in absence of reward, the authors reveal elemental behaviors conditioned by dopamine, showing VTA underlies generation of incentive value and SNc supports conditioned movement invigoration.


Parallel circuits from the bed nuclei of stria terminalis to the lateral hypothalamus drive opposing emotional states    pp1084 - 1095
William J. Giardino, Ada Eban-Rothschild, Daniel J. Christoffel, Shi-Bin Li, Robert C. Malenka et al.

Using genetically encoded physiological tools for monitoring, manipulating, and mapping discrete neural circuits, Giardino et al. characterize 2 discrete amygdala→hypothalamus pathways that promote opposite behavioral responses to emotional stimuli.


Principles governing the integration of landmark and self-motion cues in entorhinal cortical codes for navigation    pp1096 - 1106
Malcolm G. Campbell, Samuel A. Ocko, Caitlin S. Mallory, Isabel I. C. Low, Surya Ganguli et al.

Using a combination of in vivo recording and theoretical modeling, Campbell et al. develop a framework for understanding the integration of self-motion and landmark cues in entorhinal cortex and demonstrate that these principles extend to behavior.


Fragility and volatility of structural hubs in the human connectome    pp1107 - 1116
Leonardo L. Gollo, James A. Roberts, Vanessa L. Cropley, Maria A. Di Biase, Christos Pantelis et al.

Gollo et al. introduce random ‘mutations’ to the human connectome to study the trade-off between complexity vs. parsimony. The cortical hubs that are most fragile to these perturbations show the strongest loss of gray matter volume in schizophrenia.




Developmental and genetic regulation of the human cortex transcriptome illuminate schizophrenia pathogenesis    pp1117 - 1125
Andrew E. Jaffe, Richard E. Straub, Joo Heon Shin, Ran Tao, Yuan Gao et al.

The authors surveyed gene expression across cortical development and in individuals with schizophrenia. Three-fold more risk variants influenced expression than known. Risk genes showed developmental regulation, while diagnosis changes implicated largely treatment effects.


Cell-specific histone modification maps in the human frontal lobe link schizophrenia risk to the neuronal epigenome    pp1126 - 1136
Kiran Girdhar, Gabriel E. Hoffman, Yan Jiang, Leanne Brown, Marija Kundakovic et al.

This PsychENCODE resource presents 157 reference maps for open-chromatin-associated histone methylation and acetylation in prefrontal and anterior cingulate cortex, linking the neuronal epigenome to the genetic risk architecture of schizophrenia.


Amendments & Corrections


Author Correction: Selective synaptic remodeling of amygdalocortical connections associated with fear memory    p1137
Yang Yang, Dan-qian Liu, Wei Huang, Juan Deng, Yangang Sun et al.

Author Correction: Microglial immune checkpoint mechanisms    p1137
Aleksandra Deczkowska, Ido Amit & Michal Schwartz

Publisher Correction: TDP-43 gains function due to perturbed autoregulation in a Tardbp knock-in mouse model of ALS-FTD    p1138
Matthew A. White, Eosu Kim, Amanda Duffy, Robert Adalbert, Benjamin U. Phillips et al.

Publisher Correction: Thalamic projections sustain prefrontal activity during working memory maintenance    p1138
Scott S Bolkan, Joseph M Stujenske, Sebastien Parnaudeau, Timothy J Spellman, Caroline Rauffenbart et al.

Publisher Correction: Learning by neural reassociation    p1138
Matthew D. Golub, Patrick T. Sadtler, Emily R. Oby, Kristin M. Quick, Stephen I. Ryu et al.

Publisher Correction: Social deficits in Shank3-deficient mouse models of autism are rescued by histone deacetylase (HDAC) inhibition    p1139
Luye Qin, Kaijie Ma, Zi-Jun Wang, Zihua Hu, Emmanuel Matas et al.

Publisher Correction: Mutations in Vps15 perturb neuronal migration in mice and are associated with neurodevelopmental disease in humans    p1139
Thomas Gstrein, Andrew Edwards, Anna Přistoupilová, Ines Leca, Martin Breuss et al.

Publisher Correction: N6-methyladenosine RNA modification regulates embryonic neural stem cell self-renewal through histone modifications    p1139
Yang Wang, Yue Li, Minghui Yue, Jun Wang, Sandeep Kumar et al.

Nature Briefing is an essential round-up of science news, opinion and analysis, free in your inbox every weekday. With Nature Briefing, we'll keep you updated on the latest research, so you can focus on yours.

Click here to sign up.
nature events
Natureevents is a fully searchable, multi-disciplinary database designed to maximise exposure for events organisers. The contents of the Natureevents Directory are now live. The digital version is available here.
Find the latest scientific conferences, courses, meetings and symposia on natureevents.com. For event advertising opportunities across the Nature Publishing Group portfolio please contact natureevents@nature.com
More Nature Events

You have been sent this Table of Contents Alert because you have opted in to receive it. You can change or discontinue your e-mail alerts at any time, by modifying your preferences on your nature.com account at: www.nature.com/myaccount
(You will need to log in to be recognised as a nature.com registrant)

For further technical assistance, please contact our registration department

For print subscription enquiries, please contact our subscription department

For other enquiries, please contact our customer feedback department

Springer Nature | One New York Plaza, Suite 4500 | New York | NY 10004-1562 | USA

Springer Nature's worldwide offices:
London - Paris - Munich - New Delhi - Tokyo - Melbourne
San Diego - San Francisco - Washington - New York - Boston

Macmillan Publishers Limited is a company incorporated in England and Wales under company number 785998 and whose registered office is located at The Campus, 4 Crinan Street, London, N1 9XW.

© 2018 Macmillan Publishers Limited, part of Springer Nature. All Rights Reserved.

Springer Nature